pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity
Abstract The loading capacity and strategy of layered double hydroxides (LDHs) determine their suitability for drug delivery applications. In this study, two sizes of MgAl‐CO3 LDHs are converted into MgAl‐NO3 LDHs and MgAl‐Cl LDHs by an acid‐salt method. The influence of the size and type of interla...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-03-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202202396 |
| _version_ | 1797772451988373504 |
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| author | Lei Li Eliza Warszawik Patrick van Rijn |
| author_facet | Lei Li Eliza Warszawik Patrick van Rijn |
| author_sort | Lei Li |
| collection | DOAJ |
| description | Abstract The loading capacity and strategy of layered double hydroxides (LDHs) determine their suitability for drug delivery applications. In this study, two sizes of MgAl‐CO3 LDHs are converted into MgAl‐NO3 LDHs and MgAl‐Cl LDHs by an acid‐salt method. The influence of the size and type of interlayer anions of LDHs on their loading capacity are studied and compared. Here, Methylene Orange (MO) served as the anionic structure to determine the loading capacity. Due to the strongest anion‐exchange capacity of NO3− and larger interlayer distance of MgAl‐NO3 LDHs, they have impressive high loading capacities, which make these useful as absorbents or drug carriers. Additionally, the pH‐dependent release behaviors of MO‐loaded MgAl‐NO3 LDHs are investigated, which dictates both the release profile and maximum release. Above all, based on the study, it is found that the release of LDHs with agents loaded under mildly acidic environments is not based on its partial dissolution, which is commonly indicated. This study provides a better understanding of the loading and release process of LDHs, which allows for better incorporation of LDHs in biomedical‐related applications. |
| first_indexed | 2024-03-12T21:52:08Z |
| format | Article |
| id | doaj.art-572d6c6c903e41f7b8ff5541296b8e73 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-12T21:52:08Z |
| publishDate | 2023-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-572d6c6c903e41f7b8ff5541296b8e732023-07-26T01:36:15ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-03-01108n/an/a10.1002/admi.202202396pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading CapacityLei Li0Eliza Warszawik1Patrick van Rijn2Department of Biomedical Engineering‐FB40 University of Medical Center Groningen University of Groningen Groningen, A. Deusinglaan 1 9713 AV Groningen The NetherlandsDepartment of Biomedical Engineering‐FB40 University of Medical Center Groningen University of Groningen Groningen, A. Deusinglaan 1 9713 AV Groningen The NetherlandsDepartment of Biomedical Engineering‐FB40 University of Medical Center Groningen University of Groningen Groningen, A. Deusinglaan 1 9713 AV Groningen The NetherlandsAbstract The loading capacity and strategy of layered double hydroxides (LDHs) determine their suitability for drug delivery applications. In this study, two sizes of MgAl‐CO3 LDHs are converted into MgAl‐NO3 LDHs and MgAl‐Cl LDHs by an acid‐salt method. The influence of the size and type of interlayer anions of LDHs on their loading capacity are studied and compared. Here, Methylene Orange (MO) served as the anionic structure to determine the loading capacity. Due to the strongest anion‐exchange capacity of NO3− and larger interlayer distance of MgAl‐NO3 LDHs, they have impressive high loading capacities, which make these useful as absorbents or drug carriers. Additionally, the pH‐dependent release behaviors of MO‐loaded MgAl‐NO3 LDHs are investigated, which dictates both the release profile and maximum release. Above all, based on the study, it is found that the release of LDHs with agents loaded under mildly acidic environments is not based on its partial dissolution, which is commonly indicated. This study provides a better understanding of the loading and release process of LDHs, which allows for better incorporation of LDHs in biomedical‐related applications.https://doi.org/10.1002/admi.202202396anion exchangeinterlayer anionslayered double hydroxidesloading capacitypH‐responsive release |
| spellingShingle | Lei Li Eliza Warszawik Patrick van Rijn pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity Advanced Materials Interfaces anion exchange interlayer anions layered double hydroxides loading capacity pH‐responsive release |
| title | pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity |
| title_full | pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity |
| title_fullStr | pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity |
| title_full_unstemmed | pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity |
| title_short | pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity |
| title_sort | ph triggered release and degradation mechanism of layered double hydroxides with high loading capacity |
| topic | anion exchange interlayer anions layered double hydroxides loading capacity pH‐responsive release |
| url | https://doi.org/10.1002/admi.202202396 |
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