The outpost against cancer: universal cancer only markers
Cancer is the leading cause of death worldwide. Early detection of cancer can lower the mortality of all types of cancer; however, effective early-detection biomarkers are lacking for most types of cancers. DNA methylation has always been a major target of interest because DNA methylation usually oc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2023-11-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/20/11/806 |
| _version_ | 1797404109738868736 |
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| author | Chengchen Qian Xiaolong Zou Wei Li Yinshan Li Wenqiang Yu |
| author_facet | Chengchen Qian Xiaolong Zou Wei Li Yinshan Li Wenqiang Yu |
| author_sort | Chengchen Qian |
| collection | DOAJ |
| description | Cancer is the leading cause of death worldwide. Early detection of cancer can lower the mortality of all types of cancer; however, effective early-detection biomarkers are lacking for most types of cancers. DNA methylation has always been a major target of interest because DNA methylation usually occurs before other detectable genetic changes. While investigating the common features of cancer using a novel guide positioning sequencing for DNA methylation, a series of universal cancer only markers (UCOMs) have emerged as strong candidates for effective and accurate early detection of cancer. While the clinical value of current cancer biomarkers is diminished by low sensitivity and/or low specificity, the unique characteristics of UCOMs ensure clinically meaningful results. Validation of the clinical potential of UCOMs in lung, cervical, endometrial, and urothelial cancers further supports the application of UCOMs in multiple cancer types and various clinical scenarios. In fact, the applications of UCOMs are currently under active investigation with further evaluation in the early detection of cancer, auxiliary diagnosis, treatment efficacy, and recurrence monitoring. The molecular mechanisms by which UCOMs detect cancers are the next important topics to be investigated. The application of UCOMs in real-world scenarios also requires implementation and refinement. |
| first_indexed | 2024-03-09T02:50:13Z |
| format | Article |
| id | doaj.art-572e50e1798b45f19b40519daf793073 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-03-09T02:50:13Z |
| publishDate | 2023-11-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-572e50e1798b45f19b40519daf7930732023-12-05T11:51:53ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412023-11-01201180681510.20892/j.issn.2095-3941.2023.0313The outpost against cancer: universal cancer only markersChengchen Qian0Xiaolong Zou1Wei Li2Yinshan Li3Wenqiang Yu4Shanghai Epiprobe Biotechnology Co., Ltd, Shanghai 200233, ChinaDepartment of General Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, ChinaShanghai Epiprobe Biotechnology Co., Ltd, Shanghai 200233, ChinaPeople’s Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan 750002, ChinaShanghai Public Health Clinical Center & Department of General Surgery, Huashan Hospital & Cancer Metastasis Institute & Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaCancer is the leading cause of death worldwide. Early detection of cancer can lower the mortality of all types of cancer; however, effective early-detection biomarkers are lacking for most types of cancers. DNA methylation has always been a major target of interest because DNA methylation usually occurs before other detectable genetic changes. While investigating the common features of cancer using a novel guide positioning sequencing for DNA methylation, a series of universal cancer only markers (UCOMs) have emerged as strong candidates for effective and accurate early detection of cancer. While the clinical value of current cancer biomarkers is diminished by low sensitivity and/or low specificity, the unique characteristics of UCOMs ensure clinically meaningful results. Validation of the clinical potential of UCOMs in lung, cervical, endometrial, and urothelial cancers further supports the application of UCOMs in multiple cancer types and various clinical scenarios. In fact, the applications of UCOMs are currently under active investigation with further evaluation in the early detection of cancer, auxiliary diagnosis, treatment efficacy, and recurrence monitoring. The molecular mechanisms by which UCOMs detect cancers are the next important topics to be investigated. The application of UCOMs in real-world scenarios also requires implementation and refinement.https://www.cancerbiomed.org/content/20/11/806cancer detectioncancer screeningdna methylationcancer epigeneticscancer biomarkers |
| spellingShingle | Chengchen Qian Xiaolong Zou Wei Li Yinshan Li Wenqiang Yu The outpost against cancer: universal cancer only markers Cancer Biology & Medicine cancer detection cancer screening dna methylation cancer epigenetics cancer biomarkers |
| title | The outpost against cancer: universal cancer only markers |
| title_full | The outpost against cancer: universal cancer only markers |
| title_fullStr | The outpost against cancer: universal cancer only markers |
| title_full_unstemmed | The outpost against cancer: universal cancer only markers |
| title_short | The outpost against cancer: universal cancer only markers |
| title_sort | outpost against cancer universal cancer only markers |
| topic | cancer detection cancer screening dna methylation cancer epigenetics cancer biomarkers |
| url | https://www.cancerbiomed.org/content/20/11/806 |
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