Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients
AbstractObjective The serum triglyceride-glucose (TyG) index is a marker of inflammation. However, the relationship between TyG index and peritoneal dialysis-related peritonitis (PDRP) is unclear. This study aimed to investigate the potential relationship between the baseline TyG index and the initi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2267127 |
| _version_ | 1797211805917904896 |
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| author | Guiling Liu Qiqi Yan Ruifeng Wang Dandan Li Jingjing Cong Xiaoli Chen |
| author_facet | Guiling Liu Qiqi Yan Ruifeng Wang Dandan Li Jingjing Cong Xiaoli Chen |
| author_sort | Guiling Liu |
| collection | DOAJ |
| description | AbstractObjective The serum triglyceride-glucose (TyG) index is a marker of inflammation. However, the relationship between TyG index and peritoneal dialysis-related peritonitis (PDRP) is unclear. This study aimed to investigate the potential relationship between the baseline TyG index and the initial episode of PDRP.Methods A total of 208 peritoneal dialysis (PD) patients were enrolled from January 1, 2012, to December 31, 2019 and followed up until December 31, 2022. They were divided into 2 groups according to the median TyG. The primary outcome was the occurrence of the initial episode of PDRP while on PD therapy. Kaplan-Meier curves and Cox regression analyses were used to examine the association between them.Results Eighty-five initial episodes of PDRP were identified. The risk of PDRP was higher in the high-TyG index group (p = 0.030). Multivariate Cox regression analysis showed a higher risk of PDRP in patients with a high TyG index (HR = 1.800, 95% CI 1.511–2.815, p = 0.010).Conclusion The baseline serum TyG index was an independent risk factor for the initial episode of PDRP in chronic PD patients. |
| first_indexed | 2024-03-11T19:16:04Z |
| format | Article |
| id | doaj.art-573082a8344d40a18347a9f926d636d4 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T10:32:20Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-573082a8344d40a18347a9f926d636d42024-04-12T14:34:28ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145210.1080/0886022X.2023.2267127Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patientsGuiling Liu0Qiqi Yan1Ruifeng Wang2Dandan Li3Jingjing Cong4Xiaoli Chen5Department of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, ChinaDepartment of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, ChinaDepartment of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, ChinaDepartment of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, ChinaDepartment of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, ChinaDepartment of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Anhui, ChinaAbstractObjective The serum triglyceride-glucose (TyG) index is a marker of inflammation. However, the relationship between TyG index and peritoneal dialysis-related peritonitis (PDRP) is unclear. This study aimed to investigate the potential relationship between the baseline TyG index and the initial episode of PDRP.Methods A total of 208 peritoneal dialysis (PD) patients were enrolled from January 1, 2012, to December 31, 2019 and followed up until December 31, 2022. They were divided into 2 groups according to the median TyG. The primary outcome was the occurrence of the initial episode of PDRP while on PD therapy. Kaplan-Meier curves and Cox regression analyses were used to examine the association between them.Results Eighty-five initial episodes of PDRP were identified. The risk of PDRP was higher in the high-TyG index group (p = 0.030). Multivariate Cox regression analysis showed a higher risk of PDRP in patients with a high TyG index (HR = 1.800, 95% CI 1.511–2.815, p = 0.010).Conclusion The baseline serum TyG index was an independent risk factor for the initial episode of PDRP in chronic PD patients.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2267127Triglyceride-glucose indexperitoneal dialysisperitonitis |
| spellingShingle | Guiling Liu Qiqi Yan Ruifeng Wang Dandan Li Jingjing Cong Xiaoli Chen Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients Renal Failure Triglyceride-glucose index peritoneal dialysis peritonitis |
| title | Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients |
| title_full | Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients |
| title_fullStr | Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients |
| title_full_unstemmed | Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients |
| title_short | Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients |
| title_sort | elevated triglyceride glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients |
| topic | Triglyceride-glucose index peritoneal dialysis peritonitis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2267127 |
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