Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients
Worldwide, the number of elderly individuals receiving chronic hemodialysis is rising. The aim of our study was to evaluate several clinical and analytical biomarkers in chronically dialyzed patients and analyze how they change with age. A cross-sectional study was performed by evaluating 289 end-st...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/6/3325 |
| _version_ | 1797240680232255488 |
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| author | Luís Belo Maria João Valente Susana Rocha Susana Coimbra Cristina Catarino Irina Lousa Elsa Bronze-da-Rocha Petronila Rocha-Pereira Maria do Sameiro-Faria José Gerardo Oliveira José Madureira João Carlos Fernandes Vasco Miranda José Pedro L. Nunes Alice Santos-Silva |
| author_facet | Luís Belo Maria João Valente Susana Rocha Susana Coimbra Cristina Catarino Irina Lousa Elsa Bronze-da-Rocha Petronila Rocha-Pereira Maria do Sameiro-Faria José Gerardo Oliveira José Madureira João Carlos Fernandes Vasco Miranda José Pedro L. Nunes Alice Santos-Silva |
| author_sort | Luís Belo |
| collection | DOAJ |
| description | Worldwide, the number of elderly individuals receiving chronic hemodialysis is rising. The aim of our study was to evaluate several clinical and analytical biomarkers in chronically dialyzed patients and analyze how they change with age. A cross-sectional study was performed by evaluating 289 end-stage renal disease patients undergoing dialysis. We evaluated the hemogram, adipokines, the lipid profile, and several markers related to inflammation, endothelial function/fibrinolysis, nutrition, iron metabolism, and cardiac and renal fibrosis. Clinical data and dialysis efficacy parameters were obtained from all patients. The relationships between studied biomarkers and age were assessed by a statistical comparison between younger (adults with age < 65 years) and older (age ≥ 65 years) patients and by performing regression analysis. Participants presented a mean age of 68.7 years (±13.6), with 66.8% (<i>n</i> = 193) being classified as older. Compared to younger patients, older patients presented the following: (a) significantly lower values of diastolic blood pressure (DBP) and ultrafiltration volume; (b) lower levels of phosphorus, uric acid, creatinine, and albumin; and (c) higher circulating concentrations of tissue-type plasminogen activator (tPA), D-dimer, interleukin-6, leptin, <i>N</i>-terminal pro B-type natriuretic peptide, and tissue inhibitor of metalloproteinase-1. In the multiple linear regression analysis, DBP values, tPA, phosphorus, and D-dimer levels were independently associated with the age of patients (standardized betas: −0.407, 0.272, −0.230, and 0.197, respectively; <i>p</i> < 0.001 for all), demonstrating relevant changes in biomarkers with increasing age at cardiovascular and nutritional levels. These findings seem to result from crosstalk mechanisms between aging and chronic kidney disease. |
| first_indexed | 2024-04-24T18:11:17Z |
| format | Article |
| id | doaj.art-5731f0b88b4c47a3859fe09db4e34ea8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-24T18:11:17Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5731f0b88b4c47a3859fe09db4e34ea82024-03-27T13:45:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01256332510.3390/ijms25063325Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed PatientsLuís Belo0Maria João Valente1Susana Rocha2Susana Coimbra3Cristina Catarino4Irina Lousa5Elsa Bronze-da-Rocha6Petronila Rocha-Pereira7Maria do Sameiro-Faria8José Gerardo Oliveira9José Madureira10João Carlos Fernandes11Vasco Miranda12José Pedro L. Nunes13Alice Santos-Silva14UCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalHemodialysis Clinic of Porto (CHP), 4200-277 Porto, PortugalNefroServe Hemodialysis Clinic of Barcelos, 4750-110 Barcelos, PortugalNefroServe Hemodialysis Clinic of Viana do Castelo, 4901-858 Viana do Castelo, PortugalHemodialysis Clinic of Gondomar, CHD, 4420-086 Gondomar, PortugalFaculty of Medicine, University of Porto, 4200-319 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, PortugalWorldwide, the number of elderly individuals receiving chronic hemodialysis is rising. The aim of our study was to evaluate several clinical and analytical biomarkers in chronically dialyzed patients and analyze how they change with age. A cross-sectional study was performed by evaluating 289 end-stage renal disease patients undergoing dialysis. We evaluated the hemogram, adipokines, the lipid profile, and several markers related to inflammation, endothelial function/fibrinolysis, nutrition, iron metabolism, and cardiac and renal fibrosis. Clinical data and dialysis efficacy parameters were obtained from all patients. The relationships between studied biomarkers and age were assessed by a statistical comparison between younger (adults with age < 65 years) and older (age ≥ 65 years) patients and by performing regression analysis. Participants presented a mean age of 68.7 years (±13.6), with 66.8% (<i>n</i> = 193) being classified as older. Compared to younger patients, older patients presented the following: (a) significantly lower values of diastolic blood pressure (DBP) and ultrafiltration volume; (b) lower levels of phosphorus, uric acid, creatinine, and albumin; and (c) higher circulating concentrations of tissue-type plasminogen activator (tPA), D-dimer, interleukin-6, leptin, <i>N</i>-terminal pro B-type natriuretic peptide, and tissue inhibitor of metalloproteinase-1. In the multiple linear regression analysis, DBP values, tPA, phosphorus, and D-dimer levels were independently associated with the age of patients (standardized betas: −0.407, 0.272, −0.230, and 0.197, respectively; <i>p</i> < 0.001 for all), demonstrating relevant changes in biomarkers with increasing age at cardiovascular and nutritional levels. These findings seem to result from crosstalk mechanisms between aging and chronic kidney disease.https://www.mdpi.com/1422-0067/25/6/3325end-stage renal diseasedialysisagingbiomarkersbiological variables |
| spellingShingle | Luís Belo Maria João Valente Susana Rocha Susana Coimbra Cristina Catarino Irina Lousa Elsa Bronze-da-Rocha Petronila Rocha-Pereira Maria do Sameiro-Faria José Gerardo Oliveira José Madureira João Carlos Fernandes Vasco Miranda José Pedro L. Nunes Alice Santos-Silva Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients International Journal of Molecular Sciences end-stage renal disease dialysis aging biomarkers biological variables |
| title | Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients |
| title_full | Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients |
| title_fullStr | Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients |
| title_full_unstemmed | Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients |
| title_short | Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients |
| title_sort | age related changes in clinical and analytical variables in chronic hemodialyzed patients |
| topic | end-stage renal disease dialysis aging biomarkers biological variables |
| url | https://www.mdpi.com/1422-0067/25/6/3325 |
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