Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat
Injury and degeneration of tendons can be highly debilitating and can result in substantial pain, disability, and healthcare costs. Nano-sized fibers have a much wider surface area than conventionally produced fibers, which can hold composite materials more compactly and thus provide greater mechani...
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| Format: | Article |
| Language: | English |
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Iranian Veterinary Surgery Association (IVSA)
2021-05-01
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| Series: | Iranian Journal of Veterinary Surgery |
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| Online Access: | http://www.ivsajournals.com/article_126718_e21b611e6bf93d4eebd9f893ad880d34.pdf |
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| author | Seyed Mohammad Ali Sadat-Hosseini Hamid Reza Moslemi Mohammad Sadegh Nourbakhsh Sahar Ghaffari-Khaligh |
| author_facet | Seyed Mohammad Ali Sadat-Hosseini Hamid Reza Moslemi Mohammad Sadegh Nourbakhsh Sahar Ghaffari-Khaligh |
| author_sort | Seyed Mohammad Ali Sadat-Hosseini |
| collection | DOAJ |
| description | Injury and degeneration of tendons can be highly debilitating and can result in substantial pain, disability, and healthcare costs. Nano-sized fibers have a much wider surface area than conventionally produced fibers, which can hold composite materials more compactly and thus provide greater mechanical capabilities. In this study, the injured tendon was treated by electrospun PVA mats containing eucalyptus extract and histopathological results of healing were evaluated. For this study, 45 male Wistar rats were prepared and a partial thickness tenotomy was created on right hindlimbs. All rats were divided into three groups (n = 15) and three sub-groups (n = 5) including, eucalyptus extract-loaded nanofibers, PVA nanofibers, and without any treatment as a control group. Histological samples were taken on days 14, 28, and 42. The histological analysis on day 14 indicated no significant difference was observed between all groups (p > 0.05). While on days 28 and 42 post-rupture indicated a higher regenerating activity and capacity in the eucalyptus extract-loaded nanofibers than PVA nanofiber and control groups (p ≤ 0.05). In summary, these results suggest that the eucalyptus extract-loaded nanofibers mats promoted the healing process of damaged Achilles tendon in rats. |
| first_indexed | 2024-12-17T00:09:38Z |
| format | Article |
| id | doaj.art-5732db2d9fa0449c845458e360215593 |
| institution | Directory Open Access Journal |
| issn | 2008-3033 2676-6299 |
| language | English |
| last_indexed | 2024-12-17T00:09:38Z |
| publishDate | 2021-05-01 |
| publisher | Iranian Veterinary Surgery Association (IVSA) |
| record_format | Article |
| series | Iranian Journal of Veterinary Surgery |
| spelling | doaj.art-5732db2d9fa0449c845458e3602155932022-12-21T22:10:51ZengIranian Veterinary Surgery Association (IVSA)Iranian Journal of Veterinary Surgery2008-30332676-62992021-05-01161121810.30500/ivsa.2021.262669.1237126718Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in RatSeyed Mohammad Ali Sadat-Hosseini0Hamid Reza Moslemi1Mohammad Sadegh Nourbakhsh2Sahar Ghaffari-Khaligh3DVM Graduated, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.Faculty of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran.Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.Injury and degeneration of tendons can be highly debilitating and can result in substantial pain, disability, and healthcare costs. Nano-sized fibers have a much wider surface area than conventionally produced fibers, which can hold composite materials more compactly and thus provide greater mechanical capabilities. In this study, the injured tendon was treated by electrospun PVA mats containing eucalyptus extract and histopathological results of healing were evaluated. For this study, 45 male Wistar rats were prepared and a partial thickness tenotomy was created on right hindlimbs. All rats were divided into three groups (n = 15) and three sub-groups (n = 5) including, eucalyptus extract-loaded nanofibers, PVA nanofibers, and without any treatment as a control group. Histological samples were taken on days 14, 28, and 42. The histological analysis on day 14 indicated no significant difference was observed between all groups (p > 0.05). While on days 28 and 42 post-rupture indicated a higher regenerating activity and capacity in the eucalyptus extract-loaded nanofibers than PVA nanofiber and control groups (p ≤ 0.05). In summary, these results suggest that the eucalyptus extract-loaded nanofibers mats promoted the healing process of damaged Achilles tendon in rats.http://www.ivsajournals.com/article_126718_e21b611e6bf93d4eebd9f893ad880d34.pdfeucalyptus extractelectrospinningpolyvinyl alcoholachilles tendonrat |
| spellingShingle | Seyed Mohammad Ali Sadat-Hosseini Hamid Reza Moslemi Mohammad Sadegh Nourbakhsh Sahar Ghaffari-Khaligh Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat Iranian Journal of Veterinary Surgery eucalyptus extract electrospinning polyvinyl alcohol achilles tendon rat |
| title | Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat |
| title_full | Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat |
| title_fullStr | Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat |
| title_full_unstemmed | Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat |
| title_short | Evaluating the Effect of Electrospun Polyvinyl Alcohol Nanofiber Containing Eucalyptus globules Extract on the Healing of Experimental Achilles Tendon Injury in Rat |
| title_sort | evaluating the effect of electrospun polyvinyl alcohol nanofiber containing eucalyptus globules extract on the healing of experimental achilles tendon injury in rat |
| topic | eucalyptus extract electrospinning polyvinyl alcohol achilles tendon rat |
| url | http://www.ivsajournals.com/article_126718_e21b611e6bf93d4eebd9f893ad880d34.pdf |
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