“Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis”
Abstract Background Chitosan is known to inhibit the growth of many bacteria and fungi. Tissue conditioners are commonly used to prevent bone destruction under dentures. However, over time, these materials can become a suitable substrate for microbial growth. One approach to improving dental materia...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-024-03880-z |
| _version_ | 1797272957947478016 |
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| author | Sina Safari Mahmood Barani Roya Sadrmohammadi |
| author_facet | Sina Safari Mahmood Barani Roya Sadrmohammadi |
| author_sort | Sina Safari |
| collection | DOAJ |
| description | Abstract Background Chitosan is known to inhibit the growth of many bacteria and fungi. Tissue conditioners are commonly used to prevent bone destruction under dentures. However, over time, these materials can become a suitable substrate for microbial growth. One approach to improving dental materials is the use of nanoparticles. This study examined the antifungal properties of chitosan and green technique-synthesized silver nanoparticles in combination with tissue conditioners. Methods Tissue conditioner materials were mixed with chitosan and silver nanoparticles at concentrations of 0.097%, 0.19%, and 0.37%, along with 1.25 ppm Nystatin, and their antimicrobial properties against Candida albicans were investigated. The growth rate was measured after 24 h of incubation at 37 °C. Non-parametric tests, such as the Kruskal-Wallis H test and Mann-Whitney U test with Bonferroni correction, were used for data analysis after verifying that the groups did not have a normal distribution. Results Compared with the control and Nystatin groups, the Chitosan-silver groups showed a significant decrease in the number of CFUs of Candida albicans. Conclusions The combination of chitosan and silver nanoparticles with tissue conditioner materials is a promising alternative for preventing and treating denture stomatitis. These findings suggest that using very small amounts of nanoparticles in dental materials could effectively prevent microbial growth, which could improve the longevity and efficacy of dental prosthetics and materials. |
| first_indexed | 2024-03-07T14:37:43Z |
| format | Article |
| id | doaj.art-57336000d1df49c98efc9b00d7747049 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-07T14:37:43Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-57336000d1df49c98efc9b00d77470492024-03-05T20:34:14ZengBMCBMC Oral Health1472-68312024-01-012411810.1186/s12903-024-03880-z“Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis”Sina Safari0Mahmood Barani1Roya Sadrmohammadi2Student Research Committee and Department of Prosthodontics, School of Dentistry, Kerman University of Medical SciencesMedical Mycology and Bacteriology Research Center, Kerman University of Medical SciencesResident of Department of Prosthodontics, School of Dentistry, Kerman University of Medical SciencesAbstract Background Chitosan is known to inhibit the growth of many bacteria and fungi. Tissue conditioners are commonly used to prevent bone destruction under dentures. However, over time, these materials can become a suitable substrate for microbial growth. One approach to improving dental materials is the use of nanoparticles. This study examined the antifungal properties of chitosan and green technique-synthesized silver nanoparticles in combination with tissue conditioners. Methods Tissue conditioner materials were mixed with chitosan and silver nanoparticles at concentrations of 0.097%, 0.19%, and 0.37%, along with 1.25 ppm Nystatin, and their antimicrobial properties against Candida albicans were investigated. The growth rate was measured after 24 h of incubation at 37 °C. Non-parametric tests, such as the Kruskal-Wallis H test and Mann-Whitney U test with Bonferroni correction, were used for data analysis after verifying that the groups did not have a normal distribution. Results Compared with the control and Nystatin groups, the Chitosan-silver groups showed a significant decrease in the number of CFUs of Candida albicans. Conclusions The combination of chitosan and silver nanoparticles with tissue conditioner materials is a promising alternative for preventing and treating denture stomatitis. These findings suggest that using very small amounts of nanoparticles in dental materials could effectively prevent microbial growth, which could improve the longevity and efficacy of dental prosthetics and materials.https://doi.org/10.1186/s12903-024-03880-zChitosanSilver nanoparticleCandida albicansDenture stomatitisGreen synthesisAntifungal activity |
| spellingShingle | Sina Safari Mahmood Barani Roya Sadrmohammadi “Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis” BMC Oral Health Chitosan Silver nanoparticle Candida albicans Denture stomatitis Green synthesis Antifungal activity |
| title | “Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis” |
| title_full | “Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis” |
| title_fullStr | “Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis” |
| title_full_unstemmed | “Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis” |
| title_short | “Antimicrobial properties of tissue conditioner modified with chitosan and green-synthesized silver nanoparticles: a promising approach for preventing denture stomatitis” |
| title_sort | antimicrobial properties of tissue conditioner modified with chitosan and green synthesized silver nanoparticles a promising approach for preventing denture stomatitis |
| topic | Chitosan Silver nanoparticle Candida albicans Denture stomatitis Green synthesis Antifungal activity |
| url | https://doi.org/10.1186/s12903-024-03880-z |
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