Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic Activities
Six new aromatic acids (<b>1</b>–<b>6</b>) and three new leucine derivatives containing an unusual oxime moiety (<b>7</b>–<b>9</b>) were isolated and identified from the deep-sea-derived actinomycetes strain <i>Streptomyces chumphonensis</i>...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/4/259 |
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| author | Ziqi Su Kunlong Li Xiaowei Luo Yongyan Zhu Shao-Yu Mai Quanhong Zhu Bin Yang Xuefeng Zhou Huaming Tao |
| author_facet | Ziqi Su Kunlong Li Xiaowei Luo Yongyan Zhu Shao-Yu Mai Quanhong Zhu Bin Yang Xuefeng Zhou Huaming Tao |
| author_sort | Ziqi Su |
| collection | DOAJ |
| description | Six new aromatic acids (<b>1</b>–<b>6</b>) and three new leucine derivatives containing an unusual oxime moiety (<b>7</b>–<b>9</b>) were isolated and identified from the deep-sea-derived actinomycetes strain <i>Streptomyces chumphonensis</i> SCSIO15079, together with two known compounds (<b>10</b>–<b>11</b>). The structures of <b>1</b>–<b>9</b> including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds <b>1</b>–<b>9</b> were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds <b>3</b> and <b>4</b>, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied. |
| first_indexed | 2024-03-09T13:23:15Z |
| format | Article |
| id | doaj.art-573475799844447da9db969043a20af1 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T13:23:15Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-573475799844447da9db969043a20af12023-11-30T21:27:02ZengMDPI AGMarine Drugs1660-33972022-04-0120425910.3390/md20040259Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic ActivitiesZiqi Su0Kunlong Li1Xiaowei Luo2Yongyan Zhu3Shao-Yu Mai4Quanhong Zhu5Bin Yang6Xuefeng Zhou7Huaming Tao8Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaInstitute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, ChinaGuangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaGuangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaGuangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaGuangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, ChinaSix new aromatic acids (<b>1</b>–<b>6</b>) and three new leucine derivatives containing an unusual oxime moiety (<b>7</b>–<b>9</b>) were isolated and identified from the deep-sea-derived actinomycetes strain <i>Streptomyces chumphonensis</i> SCSIO15079, together with two known compounds (<b>10</b>–<b>11</b>). The structures of <b>1</b>–<b>9</b> including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds <b>1</b>–<b>9</b> were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds <b>3</b> and <b>4</b>, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.https://www.mdpi.com/1660-3397/20/4/259deep-sea actinomycetesaromatic acidsoximesantihyperlipidemic |
| spellingShingle | Ziqi Su Kunlong Li Xiaowei Luo Yongyan Zhu Shao-Yu Mai Quanhong Zhu Bin Yang Xuefeng Zhou Huaming Tao Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic Activities Marine Drugs deep-sea actinomycetes aromatic acids oximes antihyperlipidemic |
| title | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic Activities |
| title_full | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic Activities |
| title_fullStr | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic Activities |
| title_full_unstemmed | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic Activities |
| title_short | Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes <i>Streptomyces</i> <i>chumphonensis</i> SCSIO15079 with Antihyperlipidemic Activities |
| title_sort | aromatic acids and leucine derivatives produced from the deep sea actinomycetes i streptomyces i i chumphonensis i scsio15079 with antihyperlipidemic activities |
| topic | deep-sea actinomycetes aromatic acids oximes antihyperlipidemic |
| url | https://www.mdpi.com/1660-3397/20/4/259 |
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