Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort
Objective The objective of this study is to build a structural model visualising and quantifying the interrelationships of different disease outcomes with the Assessment of SpondyloArthritis International Society Health Index (ASAS HI) in patients with axial spondyloarthritis (axSpA).Methods Cross-s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-11-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/9/4/e003587.full |
| _version_ | 1827394494007345152 |
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| author | Sofia Ramiro Robert Landewé Désirée van der Heijde Maxime Dougados Annelies Boonen Jürgen Braun Uta Kiltz Imke Redeker |
| author_facet | Sofia Ramiro Robert Landewé Désirée van der Heijde Maxime Dougados Annelies Boonen Jürgen Braun Uta Kiltz Imke Redeker |
| author_sort | Sofia Ramiro |
| collection | DOAJ |
| description | Objective The objective of this study is to build a structural model visualising and quantifying the interrelationships of different disease outcomes with the Assessment of SpondyloArthritis International Society Health Index (ASAS HI) in patients with axial spondyloarthritis (axSpA).Methods Cross-sectional data collected at month 72 of the Devenir des Spondylarthropathies Indifferénciées Récentes cohort was analysed. Combining prior knowledge and observed data, probabilistic Bayesian network modelling was used to study how the interplay of different disease outcomes affects the ASAS HI, which measures disease-specific overall functioning and health. Disease outcomes comprised, among others, the Ankylosing Spondylitis (AS) Disease Activity Score (ASDAS) and the Bath AS Functional Index (BASFI).Results Data of 384 patients were analysed. The obtained structure suggests that ASAS HI is determined by both patient-reported physical function (BASFI) and disease activity (ASDAS). The parameters of the structural model show that an increase of ASDAS or BASFI by 1 unit corresponds to an increase of ASAS HI by 0.70 or 1.25 units, respectively. Moreover, the model suggests that disease activity has an indirect impact on ASAS HI via BASFI. No relationship between spinal mobility or structural damage and ASAS HI was found.Conclusions This is the first structural model developed to better understand the construct and the interplay between clinically relevant outcomes related to ASAS HI in axSpA patients. It shows that disease activity and physical function have a strong impact on ASAS HI, confirming it to be a valid construct of overall functioning and health in axSpA patients. |
| first_indexed | 2024-03-08T18:13:39Z |
| format | Article |
| id | doaj.art-5735f6508a464cf58ef6c45251ba9434 |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-03-08T18:13:39Z |
| publishDate | 2023-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-5735f6508a464cf58ef6c45251ba94342023-12-31T18:40:08ZengBMJ Publishing GroupRMD Open2056-59332023-11-019410.1136/rmdopen-2023-003587Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohortSofia Ramiro0Robert Landewé1Désirée van der Heijde2Maxime Dougados3Annelies Boonen4Jürgen Braun5Uta Kiltz6Imke Redeker7Rheumatology, Zuyderland Medical Center, Heerlen, The NetherlandsClinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Rheumatology, Leiden University Medical Center, Leiden, The NetherlandsHopital Cochin, Rheumatology, Université Paris Descartes Faculté de Médecine, Paris, FranceDepartment of Internal Medicine, Division of Rheumatology, Maastricht University Medical Centre+, Maastricht, The NetherlandsRheumazentrum Ruhrgebiet, Herne, and Department of Biochemistry, Ruhr Universität, Bochum, GermanyRheumazentrum Ruhrgebiet, Herne and Ruhr-Universität Bochum, Bochum, Germany1 Epidemiology and Health Services Research, German Rheumatism Research Centre, Berlin, GermanyObjective The objective of this study is to build a structural model visualising and quantifying the interrelationships of different disease outcomes with the Assessment of SpondyloArthritis International Society Health Index (ASAS HI) in patients with axial spondyloarthritis (axSpA).Methods Cross-sectional data collected at month 72 of the Devenir des Spondylarthropathies Indifferénciées Récentes cohort was analysed. Combining prior knowledge and observed data, probabilistic Bayesian network modelling was used to study how the interplay of different disease outcomes affects the ASAS HI, which measures disease-specific overall functioning and health. Disease outcomes comprised, among others, the Ankylosing Spondylitis (AS) Disease Activity Score (ASDAS) and the Bath AS Functional Index (BASFI).Results Data of 384 patients were analysed. The obtained structure suggests that ASAS HI is determined by both patient-reported physical function (BASFI) and disease activity (ASDAS). The parameters of the structural model show that an increase of ASDAS or BASFI by 1 unit corresponds to an increase of ASAS HI by 0.70 or 1.25 units, respectively. Moreover, the model suggests that disease activity has an indirect impact on ASAS HI via BASFI. No relationship between spinal mobility or structural damage and ASAS HI was found.Conclusions This is the first structural model developed to better understand the construct and the interplay between clinically relevant outcomes related to ASAS HI in axSpA patients. It shows that disease activity and physical function have a strong impact on ASAS HI, confirming it to be a valid construct of overall functioning and health in axSpA patients.https://rmdopen.bmj.com/content/9/4/e003587.full |
| spellingShingle | Sofia Ramiro Robert Landewé Désirée van der Heijde Maxime Dougados Annelies Boonen Jürgen Braun Uta Kiltz Imke Redeker Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort RMD Open |
| title | Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort |
| title_full | Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort |
| title_fullStr | Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort |
| title_full_unstemmed | Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort |
| title_short | Impact of disease outcomes on the Assessment of SpondyloArthritis International Society Health Index (ASAS HI): a Bayesian network analysis of the DESIR cohort |
| title_sort | impact of disease outcomes on the assessment of spondyloarthritis international society health index asas hi a bayesian network analysis of the desir cohort |
| url | https://rmdopen.bmj.com/content/9/4/e003587.full |
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