Diastereoselective Cascade Cyclization of Diazoimides with Alkylidene Pyrazolones for Preparation of Pyrazole-Fused Oxa-Bridged Oxazocines

Diastereoselective Cascade Cyclization of Diazoimides with Alkylidene Pyrazolones for Preparation of Pyrazole-Fused Oxa-Bridged Oxazocines

Under the catalysis of Rh<sub>2</sub>(OAc)<sub>4</sub> (10 mol%) and binapbisphosphine ligand (±)-<b>L3</b> (20 mol%) in DCE at 80 °C, the cascade cyclization of diazoimides with alkylidenepyrazolones underwent stereoselectively (dr > 20:1), affording pyrazole-...

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Bibliographic Details
Main Authors: Kuo Wang, Yue Zhang, Lu-Yu Cai, Xiu-Qing Song, Chen Wang, Jia-Rui Zhang, Yi-Fan Pan, Hong-Wu Zhao
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
diastereoselectivity
cascade cyclization
diazoimide
alkylidenepyrazolone
oxazocine
Online Access:https://www.mdpi.com/1420-3049/28/20/7021

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