The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothelial barrier function. Using both in vitro and ex v...

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Bibliographic Details
Main Authors: Randy E. Strauss, Louisa Mezache, Rengasayee Veeraraghavan, Robert G. Gourdie
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
Cx43
Zonula Occludens 1
barrier function
tight junctions
adherens junctions
actin cytoskeleton
Online Access:https://www.mdpi.com/2218-273X/11/8/1192

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