Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern China
Background: Increasing evidence suggests an association between elevated serum aminotransferase levels and metabolic disorders (metabolic syndrome, hyperlipemia and diabetes mellitus). However, the significance of relatively low levels of aminotransferases in relation to metabolic disorders has not...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2012-02-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/2614 |
| _version_ | 1818393806918123520 |
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| author | H Zhang Yh Ding Qm Li J Sun Sm He Xw Feng Yl Zhao Xj Zhou Yj Cai C Wang Xd Shi Zf Wang Q Zhou Jq Niu |
| author_facet | H Zhang Yh Ding Qm Li J Sun Sm He Xw Feng Yl Zhao Xj Zhou Yj Cai C Wang Xd Shi Zf Wang Q Zhou Jq Niu |
| author_sort | H Zhang |
| collection | DOAJ |
| description | Background: Increasing evidence suggests an association between elevated serum aminotransferase levels and metabolic disorders (metabolic syndrome, hyperlipemia and diabetes mellitus). However, the significance of relatively low levels of aminotransferases in relation to metabolic disorders has not been fully investigated in the general population. We investigated the association between serum amiontransferase levels and metabolic disorders using data from a survey in Jilin province, China.
Methods: In 2007, a survey was conducted throughout Jilin, China, covering both urban and rural areas. A total of 3835 people, 18 to 79 years old including 1761 men and 2074 women, underwent real-time ultrasonography, blood tests including aspartate aminotransferase and alanine aminotransferase, and had interviews with a structured questionnaire.
Results: Serum aminotransferase levels within the normal range were associated with metabolic syndrome independent of age, occupation, cultural and educational level, income, body mass index, waist circumference, smoking, and alcohol intake. Compared with the lowest level (<20 IU/L), the adjusted odds ratios for ALT levels of 20-29, 30-39, 40-49 and >50 IU/L were 1.92, 2.50, 2.97, and 3.52 in men, and 1.38 , 1.54, 3.06, and 2.62 in women, respectively. Near-normal serum aminotransferase levels associated with hyperlipemia, NAFLD, DM were also found in the study.
Conclusions: Normal to near-normal serum aminotransferase levels are associated with metabolic disorders. Serum ALT levels of 21-25 IU/L for men, and 17-22 IU/L for women are suggested as cutoff levels that detect metabolic disorders affecting the liver. |
| first_indexed | 2024-12-14T05:51:10Z |
| format | Article |
| id | doaj.art-573ddd75eb544e398ccfb355fdd6c341 |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-14T05:51:10Z |
| publishDate | 2012-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-573ddd75eb544e398ccfb355fdd6c3412022-12-21T23:14:44ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932012-02-01412Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern ChinaH Zhang0Yh Ding1Qm Li2J Sun3Sm He4Xw Feng5Yl Zhao6Xj Zhou7Yj Cai8C Wang9Xd Shi10Zf Wang11Q Zhou12Jq Niu13Dept. of Hepatology, First Hospital, Jilin University, Changchun 130021, China Background: Increasing evidence suggests an association between elevated serum aminotransferase levels and metabolic disorders (metabolic syndrome, hyperlipemia and diabetes mellitus). However, the significance of relatively low levels of aminotransferases in relation to metabolic disorders has not been fully investigated in the general population. We investigated the association between serum amiontransferase levels and metabolic disorders using data from a survey in Jilin province, China. Methods: In 2007, a survey was conducted throughout Jilin, China, covering both urban and rural areas. A total of 3835 people, 18 to 79 years old including 1761 men and 2074 women, underwent real-time ultrasonography, blood tests including aspartate aminotransferase and alanine aminotransferase, and had interviews with a structured questionnaire. Results: Serum aminotransferase levels within the normal range were associated with metabolic syndrome independent of age, occupation, cultural and educational level, income, body mass index, waist circumference, smoking, and alcohol intake. Compared with the lowest level (<20 IU/L), the adjusted odds ratios for ALT levels of 20-29, 30-39, 40-49 and >50 IU/L were 1.92, 2.50, 2.97, and 3.52 in men, and 1.38 , 1.54, 3.06, and 2.62 in women, respectively. Near-normal serum aminotransferase levels associated with hyperlipemia, NAFLD, DM were also found in the study. Conclusions: Normal to near-normal serum aminotransferase levels are associated with metabolic disorders. Serum ALT levels of 21-25 IU/L for men, and 17-22 IU/L for women are suggested as cutoff levels that detect metabolic disorders affecting the liver.https://ijph.tums.ac.ir/index.php/ijph/article/view/2614Alanine aminotransferaseMetabolic syndromeNon-alcoholic fatty liver diseaseUltrasonographyCutoff Levels |
| spellingShingle | H Zhang Yh Ding Qm Li J Sun Sm He Xw Feng Yl Zhao Xj Zhou Yj Cai C Wang Xd Shi Zf Wang Q Zhou Jq Niu Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern China Iranian Journal of Public Health Alanine aminotransferase Metabolic syndrome Non-alcoholic fatty liver disease Ultrasonography Cutoff Levels |
| title | Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern China |
| title_full | Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern China |
| title_fullStr | Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern China |
| title_full_unstemmed | Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern China |
| title_short | Relationship between Serum Aminotransferase Levels and Meta¬bolic Disord¬ers in Northern China |
| title_sort | relationship between serum aminotransferase levels and meta¬bolic disord¬ers in northern china |
| topic | Alanine aminotransferase Metabolic syndrome Non-alcoholic fatty liver disease Ultrasonography Cutoff Levels |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/2614 |
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