Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans
The mechanisms underlying biological aging are becoming recognized as therapeutic targets to delay the onset of multiple age-related morbidities. Even greater health benefits can potentially be achieved by halting or reversing age-associated changes. C. elegans restore their tissues and normal longe...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/36194 |
| _version_ | 1811253247294308352 |
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| author | Nikolay Burnaevskiy Shengying Chen Miguel Mailig Anthony Reynolds Shruti Karanth Alexander Mendenhall Marc Van Gilst Matt Kaeberlein |
| author_facet | Nikolay Burnaevskiy Shengying Chen Miguel Mailig Anthony Reynolds Shruti Karanth Alexander Mendenhall Marc Van Gilst Matt Kaeberlein |
| author_sort | Nikolay Burnaevskiy |
| collection | DOAJ |
| description | The mechanisms underlying biological aging are becoming recognized as therapeutic targets to delay the onset of multiple age-related morbidities. Even greater health benefits can potentially be achieved by halting or reversing age-associated changes. C. elegans restore their tissues and normal longevity upon exit from prolonged adult reproductive diapause, but the mechanisms underlying this phenomenon remain unknown. Here, we focused on the mechanisms controlling recovery from adult diapause. Here, we show that functional improvement of post-mitotic somatic tissues does not require germline signaling, germline stem cells, or replication of nuclear or mitochondrial DNA. Instead a large expansion of the somatic RNA pool is necessary for restoration of youthful function and longevity. Treating animals with the drug 5-fluoro-2'-deoxyuridine prevents this restoration by blocking reactivation of RNA metabolism. These observations define a critical early step during exit from adult reproductive diapause that is required for somatic rejuvenation of an adult metazoan animal. |
| first_indexed | 2024-04-12T16:47:57Z |
| format | Article |
| id | doaj.art-573eda9d98684561996ea88bd86e572d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:47:57Z |
| publishDate | 2018-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-573eda9d98684561996ea88bd86e572d2022-12-22T03:24:30ZengeLife Sciences Publications LtdeLife2050-084X2018-08-01710.7554/eLife.36194Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegansNikolay Burnaevskiy0https://orcid.org/0000-0003-1885-8999Shengying Chen1Miguel Mailig2Anthony Reynolds3Shruti Karanth4Alexander Mendenhall5https://orcid.org/0000-0002-4716-7671Marc Van Gilst6Matt Kaeberlein7https://orcid.org/0000-0002-1311-3421Department of Pathology, University of Washington, Seattle, United StatesDepartment of Pathology, University of Washington, Seattle, United StatesDepartment of Pathology, University of Washington, Seattle, United StatesDepartment of Pathology, University of Washington, Seattle, United StatesDepartment of Pathology, University of Washington, Seattle, United StatesDepartment of Pathology, University of Washington, Seattle, United StatesDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, United StatesDepartment of Pathology, University of Washington, Seattle, United StatesThe mechanisms underlying biological aging are becoming recognized as therapeutic targets to delay the onset of multiple age-related morbidities. Even greater health benefits can potentially be achieved by halting or reversing age-associated changes. C. elegans restore their tissues and normal longevity upon exit from prolonged adult reproductive diapause, but the mechanisms underlying this phenomenon remain unknown. Here, we focused on the mechanisms controlling recovery from adult diapause. Here, we show that functional improvement of post-mitotic somatic tissues does not require germline signaling, germline stem cells, or replication of nuclear or mitochondrial DNA. Instead a large expansion of the somatic RNA pool is necessary for restoration of youthful function and longevity. Treating animals with the drug 5-fluoro-2'-deoxyuridine prevents this restoration by blocking reactivation of RNA metabolism. These observations define a critical early step during exit from adult reproductive diapause that is required for somatic rejuvenation of an adult metazoan animal.https://elifesciences.org/articles/36194diapausestarvationrejuvenationribosomal RNAFUDRgermline stem cells |
| spellingShingle | Nikolay Burnaevskiy Shengying Chen Miguel Mailig Anthony Reynolds Shruti Karanth Alexander Mendenhall Marc Van Gilst Matt Kaeberlein Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans eLife diapause starvation rejuvenation ribosomal RNA FUDR germline stem cells |
| title | Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans |
| title_full | Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans |
| title_fullStr | Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans |
| title_full_unstemmed | Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans |
| title_short | Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans |
| title_sort | reactivation of rna metabolism underlies somatic restoration after adult reproductive diapause in c elegans |
| topic | diapause starvation rejuvenation ribosomal RNA FUDR germline stem cells |
| url | https://elifesciences.org/articles/36194 |
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