Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways

Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways

Objective: Swertiamarin (STM) belongs to iridoid class of compounds, and the heat-transformed products (HTPS) are produced by STM in the process of drug processing. The purpose of this study was to explore the protective effect and mechanism of STM or HTPS on acetaminophen (APAP)-induced hepatotoxic...

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Bibliographic Details
Main Authors: Qian Zhou, Qixiu Zhou, Rui Xia, Peng Zhang, Yanqing Xie, Zhuya Yang, Afsar Khan, Zhihong Zhou, Wenhong Tan, Lu Liu
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Heliyon
Subjects:
Swertia mileensis
QYD tablets
Hepatotoxicity
Acetaminophen
Mechanism
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023059546

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