Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ Damage
Elevated circulating platelet-derived extracellular vesicles (pEVs) have been associated with arterial hypertension. The role of hypertension-mediated organ damage (HMOD) to induce EV release is still unknown. We studied the micro- and macro-vascular changes (retinal vascular density and pulse wave...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/23/15150 |
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| author | Leslie Marisol Lugo-Gavidia Dylan Burger Janis M. Nolde Vance B. Matthews Markus P. Schlaich |
| author_facet | Leslie Marisol Lugo-Gavidia Dylan Burger Janis M. Nolde Vance B. Matthews Markus P. Schlaich |
| author_sort | Leslie Marisol Lugo-Gavidia |
| collection | DOAJ |
| description | Elevated circulating platelet-derived extracellular vesicles (pEVs) have been associated with arterial hypertension. The role of hypertension-mediated organ damage (HMOD) to induce EV release is still unknown. We studied the micro- and macro-vascular changes (retinal vascular density and pulse wave velocity), endothelial function (flow-mediated vasodilation of brachial artery and finger plethysmography), and assessed the psychosocial status (anxiety and depression) in hypertensive patients to determine their relationship with EV release. Pulse wave velocity showed a significant positive correlation with pEVs (r = 0.33; <i>p</i> = 0.01). Systolic blood pressure (SBP) negatively correlated with retinal vascularity. The superficial retinal vascular plexus density in the whole image showed a significant negative correlation with 24 h SBP (r = −0.38, <i>p</i> < 0.01), day-SBP (r = −0.35, <i>p</i> = 0.01), and night-SBP (r = −0.27, <i>p</i> = 0.04). pEVs did not show significant associations with microvascular damage (retinal vascular density), endothelial function (flow-mediated vasodilation of brachial artery and finger plethysmography), or psychosocial status (anxiety and depression). Our results indicate that the pEV levels were associated with macrovascular damage measured by PWV, whereas no significant association between pEVs and microvascular damage, endothelial function, or emotional status could be detected. The potential utility of pEV in clinical practice in the context of HMOD may be limited to macrovascular changes. |
| first_indexed | 2024-03-09T17:45:26Z |
| format | Article |
| id | doaj.art-573f7f74b68346d0a2e3f8c0d764dd83 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:45:26Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-573f7f74b68346d0a2e3f8c0d764dd832023-11-24T11:14:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123231515010.3390/ijms232315150Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ DamageLeslie Marisol Lugo-Gavidia0Dylan Burger1Janis M. Nolde2Vance B. Matthews3Markus P. Schlaich4Dobney Hypertension Centre, Medical School—Royal Perth Hospital Unit, Royal Perth Hospital Medical Research Foundation, The University of Western Australia, Perth, WA 6000, AustraliaKidney Research Centre, The Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, CanadaDobney Hypertension Centre, Medical School—Royal Perth Hospital Unit, Royal Perth Hospital Medical Research Foundation, The University of Western Australia, Perth, WA 6000, AustraliaDobney Hypertension Centre, Medical School—Royal Perth Hospital Unit, Royal Perth Hospital Medical Research Foundation, The University of Western Australia, Perth, WA 6000, AustraliaDobney Hypertension Centre, Medical School—Royal Perth Hospital Unit, Royal Perth Hospital Medical Research Foundation, The University of Western Australia, Perth, WA 6000, AustraliaElevated circulating platelet-derived extracellular vesicles (pEVs) have been associated with arterial hypertension. The role of hypertension-mediated organ damage (HMOD) to induce EV release is still unknown. We studied the micro- and macro-vascular changes (retinal vascular density and pulse wave velocity), endothelial function (flow-mediated vasodilation of brachial artery and finger plethysmography), and assessed the psychosocial status (anxiety and depression) in hypertensive patients to determine their relationship with EV release. Pulse wave velocity showed a significant positive correlation with pEVs (r = 0.33; <i>p</i> = 0.01). Systolic blood pressure (SBP) negatively correlated with retinal vascularity. The superficial retinal vascular plexus density in the whole image showed a significant negative correlation with 24 h SBP (r = −0.38, <i>p</i> < 0.01), day-SBP (r = −0.35, <i>p</i> = 0.01), and night-SBP (r = −0.27, <i>p</i> = 0.04). pEVs did not show significant associations with microvascular damage (retinal vascular density), endothelial function (flow-mediated vasodilation of brachial artery and finger plethysmography), or psychosocial status (anxiety and depression). Our results indicate that the pEV levels were associated with macrovascular damage measured by PWV, whereas no significant association between pEVs and microvascular damage, endothelial function, or emotional status could be detected. The potential utility of pEV in clinical practice in the context of HMOD may be limited to macrovascular changes.https://www.mdpi.com/1422-0067/23/23/15150platelet extracellular vesiclesendothelial functionorgan damagehypertension |
| spellingShingle | Leslie Marisol Lugo-Gavidia Dylan Burger Janis M. Nolde Vance B. Matthews Markus P. Schlaich Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ Damage International Journal of Molecular Sciences platelet extracellular vesicles endothelial function organ damage hypertension |
| title | Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ Damage |
| title_full | Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ Damage |
| title_fullStr | Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ Damage |
| title_full_unstemmed | Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ Damage |
| title_short | Evaluation of Circulating Platelet Extracellular Vesicles and Hypertension Mediated Organ Damage |
| title_sort | evaluation of circulating platelet extracellular vesicles and hypertension mediated organ damage |
| topic | platelet extracellular vesicles endothelial function organ damage hypertension |
| url | https://www.mdpi.com/1422-0067/23/23/15150 |
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