Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic Stroke
Background: Hemoglobin tetramers are the major oxygen-carrying molecules within the blood. We hypothesized that a lower hemoglobin level and its reduced oxygen-carrying capacity would associate with larger infarction in acute ischemic stroke patients. Methods: We studied 135 consecutive patients wit...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2011-05-01
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| Series: | Cerebrovascular Diseases Extra |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/328219 |
| _version_ | 1818277058285928448 |
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| author | W. Taylor Kimberly Ona Wu E. Murat Arsava Priya Garg Ruijun Ji Mark Vangel Aneesh B. Singhal Hakan Ay A. Gregory Sorensen |
| author_facet | W. Taylor Kimberly Ona Wu E. Murat Arsava Priya Garg Ruijun Ji Mark Vangel Aneesh B. Singhal Hakan Ay A. Gregory Sorensen |
| author_sort | W. Taylor Kimberly |
| collection | DOAJ |
| description | Background: Hemoglobin tetramers are the major oxygen-carrying molecules within the blood. We hypothesized that a lower hemoglobin level and its reduced oxygen-carrying capacity would associate with larger infarction in acute ischemic stroke patients. Methods: We studied 135 consecutive patients with acute ischemic stroke and perfusion brain MRI. We explored the association of admission hemoglobin with initial infarct volumes on acute images and the volume of infarct expansion on follow-up images. Multivariable linear regression was performed to analyze the independent effect of hemoglobin on imaging outcomes. Results: Bivariate analyses showed a significant inverse correlation between hemoglobin and initial volume in diffusion-weighted imaging (r = –0.20, p = 0.02) and absolute infarct growth (r = –0.20, p = 0.02). Multivariable linear regression modeling revealed that hemoglobin remained independently predictive of larger infarct volumes acutely (p Conclusions: Hemoglobin level at the time of acute ischemic stroke associates with larger infarcts and increased infarct growth. Clarification of the mechanism of this effect may yield novel insights for therapy. |
| first_indexed | 2024-12-12T22:55:30Z |
| format | Article |
| id | doaj.art-57413913b74f452db2bdaa4eaed71f50 |
| institution | Directory Open Access Journal |
| issn | 1664-5456 |
| language | English |
| last_indexed | 2024-12-12T22:55:30Z |
| publishDate | 2011-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Cerebrovascular Diseases Extra |
| spelling | doaj.art-57413913b74f452db2bdaa4eaed71f502022-12-22T00:08:57ZengKarger PublishersCerebrovascular Diseases Extra1664-54562011-05-0111445310.1159/000328219328219Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic StrokeW. Taylor KimberlyOna WuE. Murat ArsavaPriya GargRuijun JiMark VangelAneesh B. SinghalHakan AyA. Gregory SorensenBackground: Hemoglobin tetramers are the major oxygen-carrying molecules within the blood. We hypothesized that a lower hemoglobin level and its reduced oxygen-carrying capacity would associate with larger infarction in acute ischemic stroke patients. Methods: We studied 135 consecutive patients with acute ischemic stroke and perfusion brain MRI. We explored the association of admission hemoglobin with initial infarct volumes on acute images and the volume of infarct expansion on follow-up images. Multivariable linear regression was performed to analyze the independent effect of hemoglobin on imaging outcomes. Results: Bivariate analyses showed a significant inverse correlation between hemoglobin and initial volume in diffusion-weighted imaging (r = –0.20, p = 0.02) and absolute infarct growth (r = –0.20, p = 0.02). Multivariable linear regression modeling revealed that hemoglobin remained independently predictive of larger infarct volumes acutely (p Conclusions: Hemoglobin level at the time of acute ischemic stroke associates with larger infarcts and increased infarct growth. Clarification of the mechanism of this effect may yield novel insights for therapy.http://www.karger.com/Article/FullText/328219Acute ischemiaHemoglobinIschemiaStroke volume |
| spellingShingle | W. Taylor Kimberly Ona Wu E. Murat Arsava Priya Garg Ruijun Ji Mark Vangel Aneesh B. Singhal Hakan Ay A. Gregory Sorensen Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic Stroke Cerebrovascular Diseases Extra Acute ischemia Hemoglobin Ischemia Stroke volume |
| title | Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic Stroke |
| title_full | Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic Stroke |
| title_fullStr | Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic Stroke |
| title_full_unstemmed | Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic Stroke |
| title_short | Lower Hemoglobin Correlates with Larger Stroke Volumes in Acute Ischemic Stroke |
| title_sort | lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke |
| topic | Acute ischemia Hemoglobin Ischemia Stroke volume |
| url | http://www.karger.com/Article/FullText/328219 |
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