Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancer
PRINCIPLES: There are very limited data suggesting a benefit for second-line chemotherapy in advanced gastric cancer. Therefore, the number of patients who receive further treatment after failure of first-line chemotherapy varies considerably, ranging from 14% to 75%. In the absence of a demon...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2011-08-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/1337 |
| _version_ | 1797979599247769600 |
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| author | P Bohanes P Morel O Huber DS Courvoisier TV Perneger AD Roth |
| author_facet | P Bohanes P Morel O Huber DS Courvoisier TV Perneger AD Roth |
| author_sort | P Bohanes |
| collection | DOAJ |
| description |
PRINCIPLES: There are very limited data suggesting a benefit for second-line chemotherapy in advanced gastric cancer. Therefore, the number of patients who receive further treatment after failure of first-line chemotherapy varies considerably, ranging from 14% to 75%. In the absence of a demonstrated survival benefit of second-line chemotherapy, appropriate selection of patients based on survival predictors is essential. However, no clinico-pathologic parameters are currently widely adopted in clinical practice. We looked exclusively at Caucasian patients with metastatic gastric cancer treated with second-line chemotherapy to see if we could establish prognostic factors for survival.
METHODS: This study retrospectively evaluated 43 Caucasian patients with metastatic gastric cancer treated with second-line chemotherapy at the Geneva University Hospital. Prognostic values of clinico-pathologic parameters were analysed by Cox regression for overall survival (OS).
RESULTS:Univariate analysis found three variables to be associated with survival: progression-free survival (PFS) at first-line chemotherapy of more than 26 weeks (hazard ratio (HR) = 0.33, confidence interval (CI) 95% 0.16–0.65, p = 0.002), previous curative surgery (HR = 0.51, CI 95% 0.27–0.96, p = 0.04) and carcinoma embryonic antigen (CEA) >6.5 μg/l (HR = 1.97, CI 95% 1.06–3.65, p = 0.03).
CONCLUSIONS: In line with published data, sensitivity to previous chemotherapy identifies Caucasian patients who will survive the longest following second-line chemotherapy. A low tumour burden and previous curative gastrectomy also seem to have a positive prognostic value.
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| first_indexed | 2024-04-11T05:41:07Z |
| format | Article |
| id | doaj.art-574184310374402b8bb255429da67b49 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-11T05:41:07Z |
| publishDate | 2011-08-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-574184310374402b8bb255429da67b492022-12-22T04:42:31ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972011-08-01141333410.4414/smw.2011.13249Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancerP BohanesP MorelO HuberDS CourvoisierTV PernegerAD Roth PRINCIPLES: There are very limited data suggesting a benefit for second-line chemotherapy in advanced gastric cancer. Therefore, the number of patients who receive further treatment after failure of first-line chemotherapy varies considerably, ranging from 14% to 75%. In the absence of a demonstrated survival benefit of second-line chemotherapy, appropriate selection of patients based on survival predictors is essential. However, no clinico-pathologic parameters are currently widely adopted in clinical practice. We looked exclusively at Caucasian patients with metastatic gastric cancer treated with second-line chemotherapy to see if we could establish prognostic factors for survival. METHODS: This study retrospectively evaluated 43 Caucasian patients with metastatic gastric cancer treated with second-line chemotherapy at the Geneva University Hospital. Prognostic values of clinico-pathologic parameters were analysed by Cox regression for overall survival (OS). RESULTS:Univariate analysis found three variables to be associated with survival: progression-free survival (PFS) at first-line chemotherapy of more than 26 weeks (hazard ratio (HR) = 0.33, confidence interval (CI) 95% 0.16–0.65, p = 0.002), previous curative surgery (HR = 0.51, CI 95% 0.27–0.96, p = 0.04) and carcinoma embryonic antigen (CEA) >6.5 μg/l (HR = 1.97, CI 95% 1.06–3.65, p = 0.03). CONCLUSIONS: In line with published data, sensitivity to previous chemotherapy identifies Caucasian patients who will survive the longest following second-line chemotherapy. A low tumour burden and previous curative gastrectomy also seem to have a positive prognostic value. https://www.smw.ch/index.php/smw/article/view/1337gastric cancermetastaticprognosticsecond-line chemotherapy |
| spellingShingle | P Bohanes P Morel O Huber DS Courvoisier TV Perneger AD Roth Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancer Swiss Medical Weekly gastric cancer metastatic prognostic second-line chemotherapy |
| title | Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancer |
| title_full | Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancer |
| title_fullStr | Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancer |
| title_full_unstemmed | Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancer |
| title_short | Survival predictors for second-line chemotherapy in Caucasian patients with metastatic gastric cancer |
| title_sort | survival predictors for second line chemotherapy in caucasian patients with metastatic gastric cancer |
| topic | gastric cancer metastatic prognostic second-line chemotherapy |
| url | https://www.smw.ch/index.php/smw/article/view/1337 |
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