Ferroptosis mechanism and Alzheimer's disease
Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms. This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms. Ferroptosis is a cla...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=8;spage=1741;epage=1750;aulast= |
| _version_ | 1827300197583028224 |
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| author | Lina Feng Jingyi Sun Ling Xia Qiang Shi Yajun Hou Lili Zhang Mingquan Li Cundong Fan Baoliang Sun |
| author_facet | Lina Feng Jingyi Sun Ling Xia Qiang Shi Yajun Hou Lili Zhang Mingquan Li Cundong Fan Baoliang Sun |
| author_sort | Lina Feng |
| collection | DOAJ |
| description | Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms. This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms. Ferroptosis is a classic regulatory mode of cell death. Extensive studies of regulatory cell death in Alzheimer's disease have yielded increasing evidence that ferroptosis is closely related to the occurrence, development, and prognosis of Alzheimer's disease. This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferroptosis in Alzheimer's disease. Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer's disease. |
| first_indexed | 2024-04-24T15:48:02Z |
| format | Article |
| id | doaj.art-5741f14063a14ceeb39babef3681528b |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-24T15:48:02Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-5741f14063a14ceeb39babef3681528b2024-04-01T13:06:21ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742024-01-011981741175010.4103/1673-5374.389362Ferroptosis mechanism and Alzheimer's diseaseLina FengJingyi SunLing XiaQiang ShiYajun HouLili ZhangMingquan LiCundong FanBaoliang SunRegulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms. This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms. Ferroptosis is a classic regulatory mode of cell death. Extensive studies of regulatory cell death in Alzheimer's disease have yielded increasing evidence that ferroptosis is closely related to the occurrence, development, and prognosis of Alzheimer's disease. This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferroptosis in Alzheimer's disease. Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer's disease.http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=8;spage=1741;epage=1750;aulast=alzheimer's disease; apolipoprotein e; fe2+; ferroptosis; glial cell; glutathione peroxidase 4; imbalance in iron homeostasis; lipid peroxidation; regulated cell death; system xc– |
| spellingShingle | Lina Feng Jingyi Sun Ling Xia Qiang Shi Yajun Hou Lili Zhang Mingquan Li Cundong Fan Baoliang Sun Ferroptosis mechanism and Alzheimer's disease Neural Regeneration Research alzheimer's disease; apolipoprotein e; fe2+; ferroptosis; glial cell; glutathione peroxidase 4; imbalance in iron homeostasis; lipid peroxidation; regulated cell death; system xc– |
| title | Ferroptosis mechanism and Alzheimer's disease |
| title_full | Ferroptosis mechanism and Alzheimer's disease |
| title_fullStr | Ferroptosis mechanism and Alzheimer's disease |
| title_full_unstemmed | Ferroptosis mechanism and Alzheimer's disease |
| title_short | Ferroptosis mechanism and Alzheimer's disease |
| title_sort | ferroptosis mechanism and alzheimer s disease |
| topic | alzheimer's disease; apolipoprotein e; fe2+; ferroptosis; glial cell; glutathione peroxidase 4; imbalance in iron homeostasis; lipid peroxidation; regulated cell death; system xc– |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=8;spage=1741;epage=1750;aulast= |
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