Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides
Abstract This study investigated the role of dietary prebiotic mannan-oligosaccharides (MOS), and probiotic Bifidobacterium bifidum (BFD) in lipid metabolism, deposition, and consequent health indices in broiler chicken. The supplementation of 0.2% MOS along with either 106 or 107 CFU BFD/g feed res...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-97467-1 |
| _version_ | 1818718976911343616 |
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| author | Kapil Dev Jubeda Begum Avishek Biswas Nasir Akbar Mir Jitendra Singh Ravi Prakash Joyshikh Sonowal Krishna Bharali Simmi Tomar Rajiv Kant Neeraj Ahlawat |
| author_facet | Kapil Dev Jubeda Begum Avishek Biswas Nasir Akbar Mir Jitendra Singh Ravi Prakash Joyshikh Sonowal Krishna Bharali Simmi Tomar Rajiv Kant Neeraj Ahlawat |
| author_sort | Kapil Dev |
| collection | DOAJ |
| description | Abstract This study investigated the role of dietary prebiotic mannan-oligosaccharides (MOS), and probiotic Bifidobacterium bifidum (BFD) in lipid metabolism, deposition, and consequent health indices in broiler chicken. The supplementation of 0.2% MOS along with either 106 or 107 CFU BFD/g feed resulted in downregulation of Acetyl-CoA carboxylase, fatty acid synthase, sterolregulatory element binding protein-1, and apolipoprotein B100; and up-regulation of peroxisome proliferator activated receptor-α AMP-activated protein kinase α-1, and stearoyl CoA (∆9) desaturase-1 hepatic expression in broiler chicken. The birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed depicted lower body fat percentage, palmitic acid, stearic acid, and saturated fatty acid contents, whereas, higher palmitoleic acid, oleic acid, and MUFA contents were observed. The ∆9-desaturase indices of chicken meat have shown higher values; and elongase index (only thigh) and thioesterase index have shown lower values in birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed. The meat health indices such as Polyunsaturated fatty acids (PUFA)/Saturated fatty acids (SFA) ratio, Mono-saturated fatty acids (MUFA)/SFA ratio, unsaturated fatty acids (UFA)/SFA ratio, hypocholesterolemic/hypercholesterolemic fatty acid ratio, saturation index, atherogenic index, thrombogenic index, and hypercholesterolemic fatty acid content were positively improved in birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed. Similarly, the birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed have shown lower serum triglyceride and total cholesterol levels along with higher high density levels and improved serum health indices cardiac risk ratio, atherogenic coefficient, and, atherogenic index of plasma. |
| first_indexed | 2024-12-17T19:59:37Z |
| format | Article |
| id | doaj.art-5742894a070e4c049badbf9f4e9884b1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T19:59:37Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5742894a070e4c049badbf9f4e9884b12022-12-21T21:34:30ZengNature PortfolioScientific Reports2045-23222021-09-0111111210.1038/s41598-021-97467-1Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharidesKapil Dev0Jubeda Begum1Avishek Biswas2Nasir Akbar Mir3Jitendra Singh4Ravi Prakash5Joyshikh Sonowal6Krishna Bharali7Simmi Tomar8Rajiv Kant9Neeraj Ahlawat10ICAR-Central Avian Research InstituteCollege of Veterinary & Animal Sciences, Govind Ballabh Pant University of Agriculture & TechnologyICAR-Central Avian Research InstituteICAR-Central Avian Research InstituteCSIR-Central Drug Research InstituteCSIR-Central Drug Research InstituteICAR-Indian Veterinary Research InstituteICAR-Indian Veterinary Research InstituteICAR-Central Avian Research InstituteSam Higginbottom University of Agriculture, Technology and SciencesSam Higginbottom University of Agriculture, Technology and SciencesAbstract This study investigated the role of dietary prebiotic mannan-oligosaccharides (MOS), and probiotic Bifidobacterium bifidum (BFD) in lipid metabolism, deposition, and consequent health indices in broiler chicken. The supplementation of 0.2% MOS along with either 106 or 107 CFU BFD/g feed resulted in downregulation of Acetyl-CoA carboxylase, fatty acid synthase, sterolregulatory element binding protein-1, and apolipoprotein B100; and up-regulation of peroxisome proliferator activated receptor-α AMP-activated protein kinase α-1, and stearoyl CoA (∆9) desaturase-1 hepatic expression in broiler chicken. The birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed depicted lower body fat percentage, palmitic acid, stearic acid, and saturated fatty acid contents, whereas, higher palmitoleic acid, oleic acid, and MUFA contents were observed. The ∆9-desaturase indices of chicken meat have shown higher values; and elongase index (only thigh) and thioesterase index have shown lower values in birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed. The meat health indices such as Polyunsaturated fatty acids (PUFA)/Saturated fatty acids (SFA) ratio, Mono-saturated fatty acids (MUFA)/SFA ratio, unsaturated fatty acids (UFA)/SFA ratio, hypocholesterolemic/hypercholesterolemic fatty acid ratio, saturation index, atherogenic index, thrombogenic index, and hypercholesterolemic fatty acid content were positively improved in birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed. Similarly, the birds supplemented with 0.2% MOS along with either 106 or 107 CFU BFD/g feed have shown lower serum triglyceride and total cholesterol levels along with higher high density levels and improved serum health indices cardiac risk ratio, atherogenic coefficient, and, atherogenic index of plasma.https://doi.org/10.1038/s41598-021-97467-1 |
| spellingShingle | Kapil Dev Jubeda Begum Avishek Biswas Nasir Akbar Mir Jitendra Singh Ravi Prakash Joyshikh Sonowal Krishna Bharali Simmi Tomar Rajiv Kant Neeraj Ahlawat Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides Scientific Reports |
| title | Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides |
| title_full | Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides |
| title_fullStr | Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides |
| title_full_unstemmed | Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides |
| title_short | Hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary Bifidobacterium bifidum and mannan-oligosaccharides |
| title_sort | hepatic transcriptome analysis reveals altered lipid metabolism and consequent health indices in chicken supplemented with dietary bifidobacterium bifidum and mannan oligosaccharides |
| url | https://doi.org/10.1038/s41598-021-97467-1 |
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