Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related Cirrhosis
Aim: To evaluate health-related quality of life (HRQoL) of chronic hepatitis B (CHB) and hepatitis B virus (HBV) related cirrhosis patients and analyzed specific differences in all dimensions of HRQoL.Methods: A total of 349 patients met selection criteria were enrolled. The 36-Item Short-Form Healt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.770415/full |
| _version_ | 1798033427027460096 |
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| author | Qi Zhang Chunxiu Zhong Shaohang Cai Tao Yu Xuwen Xu Junhua Yin |
| author_facet | Qi Zhang Chunxiu Zhong Shaohang Cai Tao Yu Xuwen Xu Junhua Yin |
| author_sort | Qi Zhang |
| collection | DOAJ |
| description | Aim: To evaluate health-related quality of life (HRQoL) of chronic hepatitis B (CHB) and hepatitis B virus (HBV) related cirrhosis patients and analyzed specific differences in all dimensions of HRQoL.Methods: A total of 349 patients met selection criteria were enrolled. The 36-Item Short-Form Health Survey was adopted.Results: Results showed that the physiological HRQoL of the cirrhotic group was significantly lower than that of the non-cirrhotic group (P = 0.003), the psychological HRQoL was also lower (P = 0.006). HRQoL was significantly negatively correlated with liver stiffness (P = 0.001). We further evaluated the risk factors associated with poor HRQoL in HBV-related cirrhosis patients. Results showed that positive HBV DNA viral load (OR = 6.296, P = 0.041) and HCC family history (OR = 36.211, P = 0.001) were independent factors associated with HRQoL in HBV-related cirrhosis. For better risk stratification of patients, multivariable analyses were conducted to explore the independent factors that affected specific physiological and psychological HRQoL. In specific physiological HRQoL, results show that marital status (OR = 9.971, P = 0.034), positive HBV DNA viral load (OR = 6.202, P = 0.042) and antiviral drugs (OR = 0.45, P = 0.031) were independent factors associated with physiological HRQoL in cirrhosis patients. In psychological HRQoL, only HCC family history was independent risk factors associated with psychological HRQoL (OR = 42.684, P = 0.002).Conclusion: We found that the impaired HRQoL dimensions of HBV related cirrhosis patients differ between the various subpopulations. According to our results, risk stratification, medical decision making and personalizing interventions could be made. |
| first_indexed | 2024-04-11T20:30:18Z |
| format | Article |
| id | doaj.art-5744ac35da154227958d56fdd1418278 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-11T20:30:18Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-5744ac35da154227958d56fdd14182782022-12-22T04:04:32ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-01-011210.3389/fpsyg.2021.770415770415Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related CirrhosisQi Zhang0Chunxiu Zhong1Shaohang Cai2Tao Yu3Xuwen Xu4Junhua Yin5Department of Liver Disease Center, Shenzhen Hospital of Southern Medical University, Shenzhen, ChinaDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaAim: To evaluate health-related quality of life (HRQoL) of chronic hepatitis B (CHB) and hepatitis B virus (HBV) related cirrhosis patients and analyzed specific differences in all dimensions of HRQoL.Methods: A total of 349 patients met selection criteria were enrolled. The 36-Item Short-Form Health Survey was adopted.Results: Results showed that the physiological HRQoL of the cirrhotic group was significantly lower than that of the non-cirrhotic group (P = 0.003), the psychological HRQoL was also lower (P = 0.006). HRQoL was significantly negatively correlated with liver stiffness (P = 0.001). We further evaluated the risk factors associated with poor HRQoL in HBV-related cirrhosis patients. Results showed that positive HBV DNA viral load (OR = 6.296, P = 0.041) and HCC family history (OR = 36.211, P = 0.001) were independent factors associated with HRQoL in HBV-related cirrhosis. For better risk stratification of patients, multivariable analyses were conducted to explore the independent factors that affected specific physiological and psychological HRQoL. In specific physiological HRQoL, results show that marital status (OR = 9.971, P = 0.034), positive HBV DNA viral load (OR = 6.202, P = 0.042) and antiviral drugs (OR = 0.45, P = 0.031) were independent factors associated with physiological HRQoL in cirrhosis patients. In psychological HRQoL, only HCC family history was independent risk factors associated with psychological HRQoL (OR = 42.684, P = 0.002).Conclusion: We found that the impaired HRQoL dimensions of HBV related cirrhosis patients differ between the various subpopulations. According to our results, risk stratification, medical decision making and personalizing interventions could be made.https://www.frontiersin.org/articles/10.3389/fpsyg.2021.770415/fullliver cirrhosismental disorderantiviral treatmenthealth-related quality of lifechronic hepatitis B |
| spellingShingle | Qi Zhang Chunxiu Zhong Shaohang Cai Tao Yu Xuwen Xu Junhua Yin Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related Cirrhosis Frontiers in Psychology liver cirrhosis mental disorder antiviral treatment health-related quality of life chronic hepatitis B |
| title | Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related Cirrhosis |
| title_full | Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related Cirrhosis |
| title_fullStr | Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related Cirrhosis |
| title_full_unstemmed | Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related Cirrhosis |
| title_short | Risk Factors Associated With Quality of Life in Patients With Hepatitis B Virus Related Cirrhosis |
| title_sort | risk factors associated with quality of life in patients with hepatitis b virus related cirrhosis |
| topic | liver cirrhosis mental disorder antiviral treatment health-related quality of life chronic hepatitis B |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2021.770415/full |
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