Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia
Introduction: Menorrhagia refers to heavy menstrual cycles in which bleeding has or prolonged. Menorrhagia is a common cause for referral to gynecology clinics and about 30% of women at reproductive age experience it. Heavy menstrual bleeding has a negative impact on the quality of life in terms of...
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| Format: | Article |
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Mashhad University of Medical Sciences
2019-04-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_13200_50e4ed04ff5e90ad73461100ccf45a9f.pdf |
| _version_ | 1811328890150322176 |
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| author | Nasim Khademi Pegah Matouripour Katayoun Vakilian |
| author_facet | Nasim Khademi Pegah Matouripour Katayoun Vakilian |
| author_sort | Nasim Khademi |
| collection | DOAJ |
| description | Introduction: Menorrhagia refers to heavy menstrual cycles in which bleeding has or prolonged. Menorrhagia is a common cause for referral to gynecology clinics and about 30% of women at reproductive age experience it. Heavy menstrual bleeding has a negative impact on the quality of life in terms of physical, psychological and social health. Therefore, this study was performed with aim to determine the effect of hydro alcoholic extract ofAchillea Millefoliumon women's menorrhagia.
Methods: This triple-blind clinical trials study with control group was performed on 90 women who referred to health clinics, Arak University of Medical Sciences in 2015-2016. After one cycle of controlling menstrual bleeding, the subjects were randomly assigned to two groups of test and control. For both groups, 2 Mefenamic acid capsule (250 mg) was administered every 8 hours from the first day of menstruation up to the end of it for seven days for two consecutive cycles. For test group, in addition to Mefenamic acid, 2 Achillea Mille folium capsules was administered every 12 hours from the first day of menstruation up to the end of it for seven days. In control group, combination of mefnamic acid and placebo was administered with same dose and order. Data on the amount and duration of menstrual bleeding were analyzed using PBLAC chart. Data were analyzed using SPSS software (version20) and independent t-test, Mann-Whitney and Friedman tests. P<0.001 was considered statistically significant.
Results: In the inter-comparison of the amount and duration of menstrual bleeding before and after treatment, the amount of bleeding was significantly reduced (p<0.001); this decrease was significantly more in Achillea Mille folium group than the control group (p=0.036). The duration of menstrual bleeding was also significantly reduced in both groups (p<0.001). The decrease in duration of menstrual bleeding was significantly more in Achillea Mille folium group than the control group (p=0.042).
Conclusion: The hydro alcoholic extract ofAchillea mille folium capsule is effective in reducing the
amount and duration of menstrual bleeding in women of reproductive age. Achillea mille folium due to less complications and no hormonal effects can be effective in treatment of menorrhagia. |
| first_indexed | 2024-04-13T15:34:18Z |
| format | Article |
| id | doaj.art-5744fe7b1fad471882b844d8aedac34a |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-13T15:34:18Z |
| publishDate | 2019-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-5744fe7b1fad471882b844d8aedac34a2022-12-22T02:41:19ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632019-04-01222344110.22038/ijogi.2019.1320013200Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagiaNasim Khademi0Pegah Matouripour1Katayoun Vakilian2Instructor, Department of Midwifery, Nursing & Midwifery Sciences Development Research Center, Najaf Abad Branch, Islamic Azad University, Najaf Abad, Iran.Ph.D. of Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.Associate professor, Department of Midwifery, Ph.D. of Reproductive Health, Arak University of Medical Sciences, Arak, Iran.Introduction: Menorrhagia refers to heavy menstrual cycles in which bleeding has or prolonged. Menorrhagia is a common cause for referral to gynecology clinics and about 30% of women at reproductive age experience it. Heavy menstrual bleeding has a negative impact on the quality of life in terms of physical, psychological and social health. Therefore, this study was performed with aim to determine the effect of hydro alcoholic extract ofAchillea Millefoliumon women's menorrhagia. Methods: This triple-blind clinical trials study with control group was performed on 90 women who referred to health clinics, Arak University of Medical Sciences in 2015-2016. After one cycle of controlling menstrual bleeding, the subjects were randomly assigned to two groups of test and control. For both groups, 2 Mefenamic acid capsule (250 mg) was administered every 8 hours from the first day of menstruation up to the end of it for seven days for two consecutive cycles. For test group, in addition to Mefenamic acid, 2 Achillea Mille folium capsules was administered every 12 hours from the first day of menstruation up to the end of it for seven days. In control group, combination of mefnamic acid and placebo was administered with same dose and order. Data on the amount and duration of menstrual bleeding were analyzed using PBLAC chart. Data were analyzed using SPSS software (version20) and independent t-test, Mann-Whitney and Friedman tests. P<0.001 was considered statistically significant. Results: In the inter-comparison of the amount and duration of menstrual bleeding before and after treatment, the amount of bleeding was significantly reduced (p<0.001); this decrease was significantly more in Achillea Mille folium group than the control group (p=0.036). The duration of menstrual bleeding was also significantly reduced in both groups (p<0.001). The decrease in duration of menstrual bleeding was significantly more in Achillea Mille folium group than the control group (p=0.042). Conclusion: The hydro alcoholic extract ofAchillea mille folium capsule is effective in reducing the amount and duration of menstrual bleeding in women of reproductive age. Achillea mille folium due to less complications and no hormonal effects can be effective in treatment of menorrhagia.https://ijogi.mums.ac.ir/article_13200_50e4ed04ff5e90ad73461100ccf45a9f.pdfachilleamillefoliummefenamic acidmenorrhagia |
| spellingShingle | Nasim Khademi Pegah Matouripour Katayoun Vakilian Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān achilleamillefolium mefenamic acid menorrhagia |
| title | Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia |
| title_full | Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia |
| title_fullStr | Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia |
| title_full_unstemmed | Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia |
| title_short | Effect of hydro alcoholic extract of Achillea Millefolium on menorrhagia |
| title_sort | effect of hydro alcoholic extract of achillea millefolium on menorrhagia |
| topic | achilleamillefolium mefenamic acid menorrhagia |
| url | https://ijogi.mums.ac.ir/article_13200_50e4ed04ff5e90ad73461100ccf45a9f.pdf |
| work_keys_str_mv | AT nasimkhademi effectofhydroalcoholicextractofachilleamillefoliumonmenorrhagia AT pegahmatouripour effectofhydroalcoholicextractofachilleamillefoliumonmenorrhagia AT katayounvakilian effectofhydroalcoholicextractofachilleamillefoliumonmenorrhagia |