A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes
Abstract Background Allium hookeri is widely consumed as a vegetable and herbal medicine in Asia. A. hookeri has been reported anti-inflammatory, anti-obesity, osteoblastic, anti-oxidant, and anti-diabetic effects in animal studies. We investigated the anti-diabetic effects of A. hookeri aqueous ext...
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Complementary Medicine and Therapies |
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| Online Access: | http://link.springer.com/article/10.1186/s12906-020-03005-3 |
| _version_ | 1818922308940595200 |
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| author | Soo-Hyun Park Ui-Jin Bae Eun-Kyung Choi Su-Jin Jung Sung-Hyen Lee Jae-Heon Yang You-Suk Kim Do-Youn Jeong Hyun-Ju Kim Byung-Hyun Park Soo-Wan Chae |
| author_facet | Soo-Hyun Park Ui-Jin Bae Eun-Kyung Choi Su-Jin Jung Sung-Hyen Lee Jae-Heon Yang You-Suk Kim Do-Youn Jeong Hyun-Ju Kim Byung-Hyun Park Soo-Wan Chae |
| author_sort | Soo-Hyun Park |
| collection | DOAJ |
| description | Abstract Background Allium hookeri is widely consumed as a vegetable and herbal medicine in Asia. A. hookeri has been reported anti-inflammatory, anti-obesity, osteoblastic, anti-oxidant, and anti-diabetic effects in animal studies. We investigated the anti-diabetic effects of A. hookeri aqueous extract (AHE) in the Korean subjects. Methods Prediabetic subjects (100 ≤ fasting plasma glucose (FPG) < 126 mg/dL) who met the inclusion criteria were recruited for this study. The enrolled subjects (n = 30) were randomly divided into either an AHE (n = 15, 486 mg/day) or placebo (n = 15) group. Outcomes were measurements of FPG, glycemic response to an oral glucose tolerance test (OGTT), insulin, C-peptide, hemoglobin A1c (HbA1c), total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol. The t-test was used to assess differences between the groups. A p-value < 0.05 was considered statistically significant. Results Eight weeks after AHE supplementation, HbA1c level was significantly decreased in the AHE group compared with the placebo group. No clinically significant changes in any safety parameter were observed. Conclusion The findings suggest that AHE can be effective in reducing HbA1c, indicating it as an adjunctive tool for improving glycemic control. Trial registration The study protocol was retrospectively registered at www.clinicaltrials.gov ( NCT03330366 , October 30, 2017). |
| first_indexed | 2024-12-20T01:51:29Z |
| format | Article |
| id | doaj.art-57470c5618524ce6b64f729978ab2859 |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-12-20T01:51:29Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-57470c5618524ce6b64f729978ab28592022-12-21T19:57:37ZengBMCBMC Complementary Medicine and Therapies2662-76712020-07-012011810.1186/s12906-020-03005-3A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetesSoo-Hyun Park0Ui-Jin Bae1Eun-Kyung Choi2Su-Jin Jung3Sung-Hyen Lee4Jae-Heon Yang5You-Suk Kim6Do-Youn Jeong7Hyun-Ju Kim8Byung-Hyun Park9Soo-Wan Chae10Clinical Trial Center for Functional Foods, Chonbuk National University HospitalDepartment of Biochemistry and Molecular Biology, Chonbuk National University Medical SchoolClinical Trial Center for Functional Foods, Chonbuk National University HospitalClinical Trial Center for Functional Foods, Chonbuk National University HospitalDepartment of Agro-food Resources, National Institute of Agricultural Sciences, Rural Development AdministrationCenter for Healthcare Technology Development, Chonbuk National UniversityGoldtree Co., Ltd.Microbial Institute for Fermentation IndustryResearch Department, World Institute of KimchiDepartment of Biochemistry and Molecular Biology, Chonbuk National University Medical SchoolClinical Trial Center for Functional Foods, Chonbuk National University HospitalAbstract Background Allium hookeri is widely consumed as a vegetable and herbal medicine in Asia. A. hookeri has been reported anti-inflammatory, anti-obesity, osteoblastic, anti-oxidant, and anti-diabetic effects in animal studies. We investigated the anti-diabetic effects of A. hookeri aqueous extract (AHE) in the Korean subjects. Methods Prediabetic subjects (100 ≤ fasting plasma glucose (FPG) < 126 mg/dL) who met the inclusion criteria were recruited for this study. The enrolled subjects (n = 30) were randomly divided into either an AHE (n = 15, 486 mg/day) or placebo (n = 15) group. Outcomes were measurements of FPG, glycemic response to an oral glucose tolerance test (OGTT), insulin, C-peptide, hemoglobin A1c (HbA1c), total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol. The t-test was used to assess differences between the groups. A p-value < 0.05 was considered statistically significant. Results Eight weeks after AHE supplementation, HbA1c level was significantly decreased in the AHE group compared with the placebo group. No clinically significant changes in any safety parameter were observed. Conclusion The findings suggest that AHE can be effective in reducing HbA1c, indicating it as an adjunctive tool for improving glycemic control. Trial registration The study protocol was retrospectively registered at www.clinicaltrials.gov ( NCT03330366 , October 30, 2017).http://link.springer.com/article/10.1186/s12906-020-03005-3Allium hookeriPrediabetesPlasma glucoseOral glucose tolerance testHemoglobin A1cIncremental area under the curve |
| spellingShingle | Soo-Hyun Park Ui-Jin Bae Eun-Kyung Choi Su-Jin Jung Sung-Hyen Lee Jae-Heon Yang You-Suk Kim Do-Youn Jeong Hyun-Ju Kim Byung-Hyun Park Soo-Wan Chae A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes BMC Complementary Medicine and Therapies Allium hookeri Prediabetes Plasma glucose Oral glucose tolerance test Hemoglobin A1c Incremental area under the curve |
| title | A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes |
| title_full | A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes |
| title_fullStr | A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes |
| title_full_unstemmed | A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes |
| title_short | A randomized, double-blind, placebo-controlled crossover clinical trial to evaluate the anti-diabetic effects of Allium hookeri extract in the subjects with prediabetes |
| title_sort | randomized double blind placebo controlled crossover clinical trial to evaluate the anti diabetic effects of allium hookeri extract in the subjects with prediabetes |
| topic | Allium hookeri Prediabetes Plasma glucose Oral glucose tolerance test Hemoglobin A1c Incremental area under the curve |
| url | http://link.springer.com/article/10.1186/s12906-020-03005-3 |
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