Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study
Dyana Sarvasti,1 Isabella Lalenoh,2 Emanoel Oepangat,2 Budhi Setianto Purwowiyoto,3 Anwar Santoso,3 Rochmad Romdoni4 1Department of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University, Surabaya, Indonesia; 2Department of Cardiology, Siloam Hospital TB Simatupang, Jakarta, Indone...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-07-01
|
| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cardiovascular-protection-variables-based-on-exercise-intensity-in-sta-peer-reviewed-article-VHRM |
| _version_ | 1818204757403107328 |
|---|---|
| author | Sarvasti D Lalenoh I Oepangat E Purwowiyoto BS Santoso A Romdoni R |
| author_facet | Sarvasti D Lalenoh I Oepangat E Purwowiyoto BS Santoso A Romdoni R |
| author_sort | Sarvasti D |
| collection | DOAJ |
| description | Dyana Sarvasti,1 Isabella Lalenoh,2 Emanoel Oepangat,2 Budhi Setianto Purwowiyoto,3 Anwar Santoso,3 Rochmad Romdoni4 1Department of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University, Surabaya, Indonesia; 2Department of Cardiology, Siloam Hospital TB Simatupang, Jakarta, Indonesia; 3Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; 4Department of Cardiology and Vascular Medicine, Faculty of Medicine Airlangga University - Dr. Soetomo District General Hospital, Surabaya, IndonesiaCorrespondence: Dyana SarvastiDepartment of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University Jl, Raya Kalisari Selatan No. 1 Tower A, Lt. 6, Pakuwon City, Surabaya 60112, IndonesiaTel +628563000696Email dyana_sarvasti@yahoo.comPurpose: Our study aimed at determining and comparing the mechanism of cardiovascular protection variables in moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) in patients with stable coronary heart disease (CHD) after coronary stenting.Participants and Methods: This experimental study used the same subject and cross-over design, involving eleven stable CHD patients after coronary stenting. These were randomly divided into two groups; MICT for 29 minutes at 50– 60% heart rate reserve and HIIT with 4x4 minute intervals at 60– 80% heart rate reserve, each followed by three minutes of active recovery at 40– 50% heart rate reserve. These were conducted three times a week for two weeks. The participants’ levels of adrenaline, noradrenaline, endothelial nitric oxide synthase (eNOS), extracellular superoxide dismutase (EC-SOD) activity assayed, and flow-mediated dilatation (FMD) were examined before and after treatments were completed.Results: The HIIT significantly increased the levels of noradrenaline and eNOS compared with MICT (p< 0.05). Also, HIIT was better in maintaining EC-SOD activity and FMD compared with MICT (p< 0.05). Through the noradrenalin pathway, HIIT had a direct and significant effect on eNOS and FMD (p< 0.05) but MICT, through the noradrenaline pathways, had a direct and significant effect on eNOS (p< 0.05), and through the EC-SOD activity pathways had a direct and significant effect on FMD (p< 0.05). MICT reduced EC-SOD activity and also decreased the FMD value.Conclusion: HIIT is superior to MICT in increasing cardiovascular protection by increasing the concentrations of noradrenalin and eNOS, maintaining EC-SOD activity, and FMD in stable CHD patients after coronary stenting.Keywords: coronary heart disease, high-intensity interval training, catecholamine, eNOS, SOD, FMD |
| first_indexed | 2024-12-12T03:46:19Z |
| format | Article |
| id | doaj.art-574822a7f60f4fa79c68146e245ce71d |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-12T03:46:19Z |
| publishDate | 2020-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-574822a7f60f4fa79c68146e245ce71d2022-12-22T00:39:33ZengDove Medical PressVascular Health and Risk Management1178-20482020-07-01Volume 1625727055074Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative StudySarvasti DLalenoh IOepangat EPurwowiyoto BSSantoso ARomdoni RDyana Sarvasti,1 Isabella Lalenoh,2 Emanoel Oepangat,2 Budhi Setianto Purwowiyoto,3 Anwar Santoso,3 Rochmad Romdoni4 1Department of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University, Surabaya, Indonesia; 2Department of Cardiology, Siloam Hospital TB Simatupang, Jakarta, Indonesia; 3Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; 4Department of Cardiology and Vascular Medicine, Faculty of Medicine Airlangga University - Dr. Soetomo District General Hospital, Surabaya, IndonesiaCorrespondence: Dyana SarvastiDepartment of Internal Medicine, Faculty of Medicine Widya Mandala Catholic University Jl, Raya Kalisari Selatan No. 1 Tower A, Lt. 6, Pakuwon City, Surabaya 60112, IndonesiaTel +628563000696Email dyana_sarvasti@yahoo.comPurpose: Our study aimed at determining and comparing the mechanism of cardiovascular protection variables in moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) in patients with stable coronary heart disease (CHD) after coronary stenting.Participants and Methods: This experimental study used the same subject and cross-over design, involving eleven stable CHD patients after coronary stenting. These were randomly divided into two groups; MICT for 29 minutes at 50– 60% heart rate reserve and HIIT with 4x4 minute intervals at 60– 80% heart rate reserve, each followed by three minutes of active recovery at 40– 50% heart rate reserve. These were conducted three times a week for two weeks. The participants’ levels of adrenaline, noradrenaline, endothelial nitric oxide synthase (eNOS), extracellular superoxide dismutase (EC-SOD) activity assayed, and flow-mediated dilatation (FMD) were examined before and after treatments were completed.Results: The HIIT significantly increased the levels of noradrenaline and eNOS compared with MICT (p< 0.05). Also, HIIT was better in maintaining EC-SOD activity and FMD compared with MICT (p< 0.05). Through the noradrenalin pathway, HIIT had a direct and significant effect on eNOS and FMD (p< 0.05) but MICT, through the noradrenaline pathways, had a direct and significant effect on eNOS (p< 0.05), and through the EC-SOD activity pathways had a direct and significant effect on FMD (p< 0.05). MICT reduced EC-SOD activity and also decreased the FMD value.Conclusion: HIIT is superior to MICT in increasing cardiovascular protection by increasing the concentrations of noradrenalin and eNOS, maintaining EC-SOD activity, and FMD in stable CHD patients after coronary stenting.Keywords: coronary heart disease, high-intensity interval training, catecholamine, eNOS, SOD, FMDhttps://www.dovepress.com/cardiovascular-protection-variables-based-on-exercise-intensity-in-sta-peer-reviewed-article-VHRMcoronary heart diseasehigh-intensity interval trainingcatecholamineenossodfmd. |
| spellingShingle | Sarvasti D Lalenoh I Oepangat E Purwowiyoto BS Santoso A Romdoni R Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study Vascular Health and Risk Management coronary heart disease high-intensity interval training catecholamine enos sod fmd. |
| title | Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study |
| title_full | Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study |
| title_fullStr | Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study |
| title_full_unstemmed | Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study |
| title_short | Cardiovascular Protection Variables Based on Exercise Intensity in Stable Coronary Heart Disease Patients After Coronary Stenting: A Comparative Study |
| title_sort | cardiovascular protection variables based on exercise intensity in stable coronary heart disease patients after coronary stenting a comparative study |
| topic | coronary heart disease high-intensity interval training catecholamine enos sod fmd. |
| url | https://www.dovepress.com/cardiovascular-protection-variables-based-on-exercise-intensity-in-sta-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT sarvastid cardiovascularprotectionvariablesbasedonexerciseintensityinstablecoronaryheartdiseasepatientsaftercoronarystentingacomparativestudy AT lalenohi cardiovascularprotectionvariablesbasedonexerciseintensityinstablecoronaryheartdiseasepatientsaftercoronarystentingacomparativestudy AT oepangate cardiovascularprotectionvariablesbasedonexerciseintensityinstablecoronaryheartdiseasepatientsaftercoronarystentingacomparativestudy AT purwowiyotobs cardiovascularprotectionvariablesbasedonexerciseintensityinstablecoronaryheartdiseasepatientsaftercoronarystentingacomparativestudy AT santosoa cardiovascularprotectionvariablesbasedonexerciseintensityinstablecoronaryheartdiseasepatientsaftercoronarystentingacomparativestudy AT romdonir cardiovascularprotectionvariablesbasedonexerciseintensityinstablecoronaryheartdiseasepatientsaftercoronarystentingacomparativestudy |