Quality of life of the mechanically ventilated patients with community-acquired pneumonia
Background/Aim. Patients with pneumonia who require mechanical ventilation (MV) are associated with several poor outcomes such as prolonged hospitalization, higher rate of mortality and increased spread of antibioticsresistant pathogens. MV in patients with communityacquired pneumonia (CAP) could ca...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2018-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700008Z.pdf |
| _version_ | 1811332694306455552 |
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| author | Zornić Nenad Milovanović Dragan R. Stojadinović Miroslav Radovanović Dragče Davidović Goran Simović Stefan Bukumirić Zoran Janjić Vladimir Marić Nebojša Jevđić Jasna Rosić Vesna Nešić Jelena |
| author_facet | Zornić Nenad Milovanović Dragan R. Stojadinović Miroslav Radovanović Dragče Davidović Goran Simović Stefan Bukumirić Zoran Janjić Vladimir Marić Nebojša Jevđić Jasna Rosić Vesna Nešić Jelena |
| author_sort | Zornić Nenad |
| collection | DOAJ |
| description | Background/Aim. Patients with pneumonia who require mechanical ventilation (MV) are associated with several poor outcomes such as prolonged hospitalization, higher rate of mortality and increased spread of antibioticsresistant pathogens. MV in patients with communityacquired pneumonia (CAP) could cause development of psychological symptoms, often neglected in the Intensive Care Units (ICU) as well as decreased quality of life after the withdrawal of the MV. The aim of the study was to evaluate the quality of life in patients with CAPs treated with MV in ICU. Methods. The study was designed as a cohort study of hospital-treated patients with CAP with prospective data collection. The quality of life was defined as the primary outcome, while the use of MV was assumed as the primary prognostic factor that adversely affected the outcome. The patients were recruited from the population of patients with CAPs who were hospitalized at the ICU, Clinical Center Kragujevac, Serbia, from January 2013 to January 2014. The experimental group consisted of patients who were on MV while the control group included patients who were treated for CPAs in the ICU, but were not subjected to MV. The quality of life was assessed by using patient-rated Euro Quality of Life (EuroQoL) Group-EQ-5D index. The calculation of the total EQ-5D-5L score values was performed by using the predefined, validated mapping key according to response combinations. Statistical analysis was performed by using χ2 test, Student's t-test, univariate and multivariate logistic regression analyses. Results. The patients with MV had worse EQ5D-5L values in comparison to the control group for all 5 domains. Mobility, self-care and usual activities were negatively affected during the whole follow-up period. Pain or discomfort and anxiety or depression differed significantly between the study group and the control group at days 7 and 30. Conclusion. Patients with MV tend to have poorer quality of life, especially in 3 domains. The main reasons are the presence of chronic comorbidities in the population that require MV. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175007] |
| first_indexed | 2024-04-13T16:40:50Z |
| format | Article |
| id | doaj.art-57485b1accb34b71b04a233b78cc678b |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-04-13T16:40:50Z |
| publishDate | 2018-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-57485b1accb34b71b04a233b78cc678b2022-12-22T02:39:14ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202018-01-0175986487410.2298/VSP160905008Z0042-84501700008ZQuality of life of the mechanically ventilated patients with community-acquired pneumoniaZornić Nenad0Milovanović Dragan R.1Stojadinović Miroslav2Radovanović Dragče3Davidović Goran4Simović Stefan5Bukumirić Zoran6Janjić Vladimir7Marić Nebojša8Jevđić Jasna9Rosić Vesna10Nešić Jelena11Faculty of Medical Sciences, Clinical Center “Kragujevac”, Department for Anesthesiology and Reanimation, KragujevacFaculty of Medical Sciences, Clinical Center “Kragujevac”, Department for Clinical Pharmacology, KragujevacFaculty of Medical Sciences, Clinical Center “Kragujevac”, Clinic for Nephrology and Urology, KragujevacFaculty of Medical Sciences, Clinical Center “Kragujevac”, Clinic for Surgery, KragujevacFaculty of Medical Sciences, Clinical Center “Kragujevac”, Clinic for Cardiology, KragujevacFaculty of Medical Sciences, Clinical Center “Kragujevac”, Clinic for Cardiology, KragujevacFaculty of Medicine, Institute for Medical Statistics and Informatics, BelgradeFaculty of Medical Sciences, Clinical Center “Kragujevac”, Department of Psychiatry, KragujevacMilitary Medical Academy, Department of Thoracic Surgery, BelgradeFaculty of Medical Sciences, Clinical Center “Kragujevac”, Department for Anesthesiology and Reanimation, KragujevacFaculty of Medical Sciences, Clinical Center “Kragujevac”, ‡‡Department for Histology, KragujevacFaculty of Medical Sciences, Clinical Center “Kragujevac”, Clinic for Cardiology, KragujevacBackground/Aim. Patients with pneumonia who require mechanical ventilation (MV) are associated with several poor outcomes such as prolonged hospitalization, higher rate of mortality and increased spread of antibioticsresistant pathogens. MV in patients with communityacquired pneumonia (CAP) could cause development of psychological symptoms, often neglected in the Intensive Care Units (ICU) as well as decreased quality of life after the withdrawal of the MV. The aim of the study was to evaluate the quality of life in patients with CAPs treated with MV in ICU. Methods. The study was designed as a cohort study of hospital-treated patients with CAP with prospective data collection. The quality of life was defined as the primary outcome, while the use of MV was assumed as the primary prognostic factor that adversely affected the outcome. The patients were recruited from the population of patients with CAPs who were hospitalized at the ICU, Clinical Center Kragujevac, Serbia, from January 2013 to January 2014. The experimental group consisted of patients who were on MV while the control group included patients who were treated for CPAs in the ICU, but were not subjected to MV. The quality of life was assessed by using patient-rated Euro Quality of Life (EuroQoL) Group-EQ-5D index. The calculation of the total EQ-5D-5L score values was performed by using the predefined, validated mapping key according to response combinations. Statistical analysis was performed by using χ2 test, Student's t-test, univariate and multivariate logistic regression analyses. Results. The patients with MV had worse EQ5D-5L values in comparison to the control group for all 5 domains. Mobility, self-care and usual activities were negatively affected during the whole follow-up period. Pain or discomfort and anxiety or depression differed significantly between the study group and the control group at days 7 and 30. Conclusion. Patients with MV tend to have poorer quality of life, especially in 3 domains. The main reasons are the presence of chronic comorbidities in the population that require MV. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175007]http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700008Z.pdfrespiration, artificialpneumoniacritical carequality of lifeprognosis |
| spellingShingle | Zornić Nenad Milovanović Dragan R. Stojadinović Miroslav Radovanović Dragče Davidović Goran Simović Stefan Bukumirić Zoran Janjić Vladimir Marić Nebojša Jevđić Jasna Rosić Vesna Nešić Jelena Quality of life of the mechanically ventilated patients with community-acquired pneumonia Vojnosanitetski Pregled respiration, artificial pneumonia critical care quality of life prognosis |
| title | Quality of life of the mechanically ventilated patients with community-acquired pneumonia |
| title_full | Quality of life of the mechanically ventilated patients with community-acquired pneumonia |
| title_fullStr | Quality of life of the mechanically ventilated patients with community-acquired pneumonia |
| title_full_unstemmed | Quality of life of the mechanically ventilated patients with community-acquired pneumonia |
| title_short | Quality of life of the mechanically ventilated patients with community-acquired pneumonia |
| title_sort | quality of life of the mechanically ventilated patients with community acquired pneumonia |
| topic | respiration, artificial pneumonia critical care quality of life prognosis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2018/0042-84501700008Z.pdf |
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