Oral lesions associated with hydroxyurea treatment
Hydroxyurea (HU) is an antimetabolic agent commonly used in myeloproliferative disorders and hematological diseases as well as in severe psoriasis. Despite of usually be well tolerated, sometimes it can induce immunosuppression and mucocutaneous adverse effects associated with discomfort or pain. Ne...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=6;spage=869;epage=870;aulast=Mendonça |
| _version_ | 1818516994011430912 |
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| author | Regina Mendonça Luiz Alcino Gueiros Kátia Capellaro Vitória Régia Pereira Pinheiro Márcio Ajudarte Lopes |
| author_facet | Regina Mendonça Luiz Alcino Gueiros Kátia Capellaro Vitória Régia Pereira Pinheiro Márcio Ajudarte Lopes |
| author_sort | Regina Mendonça |
| collection | DOAJ |
| description | Hydroxyurea (HU) is an antimetabolic agent commonly used in myeloproliferative disorders and hematological diseases as well as in severe psoriasis. Despite of usually be well tolerated, sometimes it can induce immunosuppression and mucocutaneous adverse effects associated with discomfort or pain. Nevertheless, oral mucosal adverse reactions are extremely uncommon and present as ulcers, tongue depapilation and dyschromia. Complete remission of adverse effects is usually observed after withdrawal of the medication. The aim of this paper is to report two patients with oral lesions related to HU treatment. T0 he patients were adequately managed by changing hydroxyurea with imatinib mesilate. Oral lesions are rare complications of long-term hydroxyurea treatment and may be an indication of stopping therapy and substitution with imatinib mesilate. |
| first_indexed | 2024-12-11T00:50:00Z |
| format | Article |
| id | doaj.art-574aa2e2837b4c009ed130c9065fcb42 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-12-11T00:50:00Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-574aa2e2837b4c009ed130c9065fcb422022-12-22T01:26:39ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032011-01-0122686987010.4103/0970-9290.94690Oral lesions associated with hydroxyurea treatmentRegina MendonçaLuiz Alcino GueirosKátia CapellaroVitória Régia Pereira PinheiroMárcio Ajudarte LopesHydroxyurea (HU) is an antimetabolic agent commonly used in myeloproliferative disorders and hematological diseases as well as in severe psoriasis. Despite of usually be well tolerated, sometimes it can induce immunosuppression and mucocutaneous adverse effects associated with discomfort or pain. Nevertheless, oral mucosal adverse reactions are extremely uncommon and present as ulcers, tongue depapilation and dyschromia. Complete remission of adverse effects is usually observed after withdrawal of the medication. The aim of this paper is to report two patients with oral lesions related to HU treatment. T0 he patients were adequately managed by changing hydroxyurea with imatinib mesilate. Oral lesions are rare complications of long-term hydroxyurea treatment and may be an indication of stopping therapy and substitution with imatinib mesilate.http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=6;spage=869;epage=870;aulast=MendonçaAdverse effectshydroxyureaoral lesions |
| spellingShingle | Regina Mendonça Luiz Alcino Gueiros Kátia Capellaro Vitória Régia Pereira Pinheiro Márcio Ajudarte Lopes Oral lesions associated with hydroxyurea treatment Indian Journal of Dental Research Adverse effects hydroxyurea oral lesions |
| title | Oral lesions associated with hydroxyurea treatment |
| title_full | Oral lesions associated with hydroxyurea treatment |
| title_fullStr | Oral lesions associated with hydroxyurea treatment |
| title_full_unstemmed | Oral lesions associated with hydroxyurea treatment |
| title_short | Oral lesions associated with hydroxyurea treatment |
| title_sort | oral lesions associated with hydroxyurea treatment |
| topic | Adverse effects hydroxyurea oral lesions |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2011;volume=22;issue=6;spage=869;epage=870;aulast=Mendonça |
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