Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats
Background: Aluminium (Al) intoxication was recognised as a causal agent in p a t i ent s undergoing haemodialysis and then was linked to Alzheimer's disease. Nevertheless, environmental pollution with Al is mainly v i a drinking water, particularly when acidic rain falls on Al containing soil...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2009-07-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1205 |
| _version_ | 1797333010975031296 |
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| author | Mehdi I. Hilmy Omer A. M. Al-Habib |
| author_facet | Mehdi I. Hilmy Omer A. M. Al-Habib |
| author_sort | Mehdi I. Hilmy |
| collection | DOAJ |
| description | Background: Aluminium (Al) intoxication was recognised as a causal agent in p a t i ent s undergoing haemodialysis and then was linked to Alzheimer's disease. Nevertheless, environmental pollution with Al is mainly v i a drinking water, particularly when acidic rain falls on Al containing soil and bedrock. In addition, aluminium utens i l s are widely used for cooking. Therefore, an increasing concern is emerging for the role of pH in the absorption of aluminium from ingested food.
Materials and methods: The objective of this study was to establish the effect of acidification with1 ml/dL of concentrated acetic acid on the absorption of aluminium from a 5 mM a l u mi n i u m sulphate\ solution taken orally in albino rats. Levels of Al, Ca, Cu, and Fe in plasma. brain, kidney, and liver were measured by atomic absorption.
Results: The results indicate that acidification of Al salt solut ion wi t h acetic acid enhances its absorption. Increased plasma Al level (p<0.05) was associated with increased deposition in all tissues and a reduced overall body mass (p<0.05) and mass of cerebral hemispheres (p<0.01) re la t ive to the controls. The increased plasma levels of Al correlated positively with increased Al deposited in the kidney (r =0.790) l ive r (r = 0.967), and b r a i n (r=0.955) despite the blood brain barrier. Increased Al also correlated negatively with levels of Ca, Cu, and Fe in all tissues except in brain in which there was a positive correlation with Ca deposition.
Conclusion: The study shows an increased absorption and deposition of Al in the tissues from rats ingesting acidified Al solution with acetic acid. |
| first_indexed | 2024-03-08T07:57:41Z |
| format | Article |
| id | doaj.art-574c0fa97a8747ad90616aa906c9d0b4 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T07:57:41Z |
| publishDate | 2009-07-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-574c0fa97a8747ad90616aa906c9d0b42024-02-02T13:11:18ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572009-07-0151210.32007/1205%g169-173Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino ratsMehdi I. Hilmy0Omer A. M. Al-Habib1Department of Physiology, College of Medicine, Baghdad University.Department of Biology, College of Sciences, Jordan University.Background: Aluminium (Al) intoxication was recognised as a causal agent in p a t i ent s undergoing haemodialysis and then was linked to Alzheimer's disease. Nevertheless, environmental pollution with Al is mainly v i a drinking water, particularly when acidic rain falls on Al containing soil and bedrock. In addition, aluminium utens i l s are widely used for cooking. Therefore, an increasing concern is emerging for the role of pH in the absorption of aluminium from ingested food. Materials and methods: The objective of this study was to establish the effect of acidification with1 ml/dL of concentrated acetic acid on the absorption of aluminium from a 5 mM a l u mi n i u m sulphate\ solution taken orally in albino rats. Levels of Al, Ca, Cu, and Fe in plasma. brain, kidney, and liver were measured by atomic absorption. Results: The results indicate that acidification of Al salt solut ion wi t h acetic acid enhances its absorption. Increased plasma Al level (p<0.05) was associated with increased deposition in all tissues and a reduced overall body mass (p<0.05) and mass of cerebral hemispheres (p<0.01) re la t ive to the controls. The increased plasma levels of Al correlated positively with increased Al deposited in the kidney (r =0.790) l ive r (r = 0.967), and b r a i n (r=0.955) despite the blood brain barrier. Increased Al also correlated negatively with levels of Ca, Cu, and Fe in all tissues except in brain in which there was a positive correlation with Ca deposition. Conclusion: The study shows an increased absorption and deposition of Al in the tissues from rats ingesting acidified Al solution with acetic acid.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1205Aluminum absorption, acetic acid, brain atrophy. |
| spellingShingle | Mehdi I. Hilmy Omer A. M. Al-Habib Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats مجلة كلية الطب Aluminum absorption, acetic acid, brain atrophy. |
| title | Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats |
| title_full | Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats |
| title_fullStr | Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats |
| title_full_unstemmed | Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats |
| title_short | Enteral intake of Aluminum Sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats |
| title_sort | enteral intake of aluminum sulphate in acidic medium enhances absorption and alters tissue content of other trace elements in male albino rats |
| topic | Aluminum absorption, acetic acid, brain atrophy. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1205 |
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