Association of hepatitis C virus NS5B variants with resistance to new antiviral drugs among untreated patients

Association of hepatitis C virus NS5B variants with resistance to new antiviral drugs among untreated patients

Mutations located in the 109-amino acid fragment of NS5B are typically associated with resistance to interferon (IFN) and ribavirin (RIB) and to new antiviral drugs. The prevalence of these mutations was examined in 69 drug-naïve individuals with hepatitis C virus (HCV) infections in Rio de Janeiro,...

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Bibliographic Details
Main Authors: Magda Cristina Bernardino Castilho, Angélica Nascimento Martins, Ingrid Siciliano Horbach, Renata de Mello Perez, Fatima Aparecida Ferreira Figueiredo, Paulo de Tarso Aparecida Pinto, Leticia Cancela Nabuco, Dirce Bonfim de Lima, Amílcar Tanuri, Luis Cristóvão Porto, Orlando da Costa Ferreira Júnior
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2011-12-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
HCV
NS5B
genotyping
Brazilian sequences
resistance mutation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800011&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800011&lng=en&tlng=en

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