Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22)
Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD) is a subtype of mastocytosis associated commonly with myeloid neoplasms, Non-Hodgkin′s lymphoma, or other hematological neoplasms. In these conditions, mastocytosis needs to be differentiated from mast...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=3;spage=409;epage=412;aulast=Gadage |
| _version_ | 1819048919866277888 |
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| author | V S Gadage P S Kadam Amare K S Galani N Mittal |
| author_facet | V S Gadage P S Kadam Amare K S Galani N Mittal |
| author_sort | V S Gadage |
| collection | DOAJ |
| description | Systemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD) is a subtype of mastocytosis associated commonly with myeloid neoplasms, Non-Hodgkin′s lymphoma, or other hematological neoplasms. In these conditions, mastocytosis needs to be differentiated from mast cell hyperplasia or mast cell activation states. Neoplastic nature of mastocytosis is proved either by morphology, aberrant immunophenotype, or detection of point mutation at codon-816 of c-kit gene. This is a rare entity, even more so in pediatric population. Herein, we report a case of 14-year-old girl with SM associated with acute myeloid leukemia with maturation with t(8;21). Multifocal dense infiltrate of spindle-shaped mast cells on bone marrow aspirate and biopsy with coexpression of CD2 and CD25 by flow cytometric analysis proved the SM component at the time of diagnosis and persistence at post induction status also. |
| first_indexed | 2024-12-21T11:23:55Z |
| format | Article |
| id | doaj.art-574fa152abdc473db81e225dfc113da8 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-21T11:23:55Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-574fa152abdc473db81e225dfc113da82022-12-21T19:05:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292012-01-0155340941210.4103/0377-4929.101761Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22)V S GadageP S Kadam AmareK S GalaniN MittalSystemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD) is a subtype of mastocytosis associated commonly with myeloid neoplasms, Non-Hodgkin′s lymphoma, or other hematological neoplasms. In these conditions, mastocytosis needs to be differentiated from mast cell hyperplasia or mast cell activation states. Neoplastic nature of mastocytosis is proved either by morphology, aberrant immunophenotype, or detection of point mutation at codon-816 of c-kit gene. This is a rare entity, even more so in pediatric population. Herein, we report a case of 14-year-old girl with SM associated with acute myeloid leukemia with maturation with t(8;21). Multifocal dense infiltrate of spindle-shaped mast cells on bone marrow aspirate and biopsy with coexpression of CD2 and CD25 by flow cytometric analysis proved the SM component at the time of diagnosis and persistence at post induction status also.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=3;spage=409;epage=412;aulast=GadageAcute leukemiaacute myeloid leukemiamastocytosis |
| spellingShingle | V S Gadage P S Kadam Amare K S Galani N Mittal Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22) Indian Journal of Pathology and Microbiology Acute leukemia acute myeloid leukemia mastocytosis |
| title | Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22) |
| title_full | Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22) |
| title_fullStr | Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22) |
| title_full_unstemmed | Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22) |
| title_short | Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22) |
| title_sort | systemic mastocytosis with associated acute myeloid leukemia with t 8 21 q22 q22 |
| topic | Acute leukemia acute myeloid leukemia mastocytosis |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=3;spage=409;epage=412;aulast=Gadage |
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