Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome
Abstract Objective: Multisystem inflammatory syndrome in children (MIS-C), is a newly recognised life-threatening complication of coronavirus disease 2019 (COVID-19). Early determination of clinical severity of the disease is important for early decision of treatment regimens. The aim of this study...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selçuk University
2022-08-01
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| Series: | Genel Tıp Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2377438 |
| _version_ | 1797686557481631744 |
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| author | Gülsüm Alkan Melike Emiroğlu Şadiye Kübra Tüter Öz Ahmet Sert |
| author_facet | Gülsüm Alkan Melike Emiroğlu Şadiye Kübra Tüter Öz Ahmet Sert |
| author_sort | Gülsüm Alkan |
| collection | DOAJ |
| description | Abstract
Objective:
Multisystem inflammatory syndrome in children (MIS-C), is a newly recognised life-threatening complication of coronavirus disease 2019 (COVID-19). Early determination of clinical severity of the disease is important for early decision of treatment regimens. The aim of this study is to investigate the severity classification value of a number of hematological parameters, inflammatory markers and biochemical tests in patients with MIS-C during the acute stage and after anti-inflammatory treatment.
Material and Methods:
In this retrospective case-controlled study, 64 children with MIS-C and 95 healthy age and gender matched children were included. Patients were divided into three clinical severity groups; mild, moderate, and severe.
Results:
Mean platelet volume (MPV), MPV to lymphocyte ratio (MPVLR), D-dimer, ferritin, interleukin 6 (IL-6) levels were significantly higher, while albumin levels were lower in the severe MIS-C group compared to all the other groups on admission. Neutrophil-to-lymphocyte ratio (NLR) and derived (d) NLR (d-NLR) levels were significantly higher in the moderate group compared to the mild group. In the pre-treatment period of MIS-C patients had higher MPV, platelet distribution width (PDW) values while they had lower white blood cell, lymphocyte, monocyte, haemoglobin, mean corpuscular volume (MCV), red cell distribution width (RDW), plateletcrit and platelet values compared to the post-treatment group.
Lymphocyte, platelets, and haemoglobin levels were significantly higher in the control group compared to the pre-treatment group. Acute phase reactants, NLR, NMR, PLR, d-NLR, MPVLR and systemic inflammatory index were significantly higher in all MIS-C patients on admission compared to the control group.
Conclusion: Specific routine laboratory test results may be useful in determining disease severity of MIS-C, possibly predict the prognosis and allow early initiation of the appropriate treatment. |
| first_indexed | 2024-03-12T01:06:49Z |
| format | Article |
| id | doaj.art-5758dbe68a964c23ace5435fcfc91bea |
| institution | Directory Open Access Journal |
| issn | 2602-3741 |
| language | English |
| last_indexed | 2024-03-12T01:06:49Z |
| publishDate | 2022-08-01 |
| publisher | Selçuk University |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj.art-5758dbe68a964c23ace5435fcfc91bea2023-09-14T08:47:57ZengSelçuk UniversityGenel Tıp Dergisi2602-37412022-08-0132441542410.54005/geneltip.1104257154Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory SyndromeGülsüm Alkan0Melike Emiroğlu1Şadiye Kübra Tüter Öz2Ahmet Sert3SELÇUK ÜNİVERSİTESİSELÇUK ÜNİVERSİTESİSELÇUK ÜNİVERSİTESİSELÇUK ÜNİVERSİTESİAbstract Objective: Multisystem inflammatory syndrome in children (MIS-C), is a newly recognised life-threatening complication of coronavirus disease 2019 (COVID-19). Early determination of clinical severity of the disease is important for early decision of treatment regimens. The aim of this study is to investigate the severity classification value of a number of hematological parameters, inflammatory markers and biochemical tests in patients with MIS-C during the acute stage and after anti-inflammatory treatment. Material and Methods: In this retrospective case-controlled study, 64 children with MIS-C and 95 healthy age and gender matched children were included. Patients were divided into three clinical severity groups; mild, moderate, and severe. Results: Mean platelet volume (MPV), MPV to lymphocyte ratio (MPVLR), D-dimer, ferritin, interleukin 6 (IL-6) levels were significantly higher, while albumin levels were lower in the severe MIS-C group compared to all the other groups on admission. Neutrophil-to-lymphocyte ratio (NLR) and derived (d) NLR (d-NLR) levels were significantly higher in the moderate group compared to the mild group. In the pre-treatment period of MIS-C patients had higher MPV, platelet distribution width (PDW) values while they had lower white blood cell, lymphocyte, monocyte, haemoglobin, mean corpuscular volume (MCV), red cell distribution width (RDW), plateletcrit and platelet values compared to the post-treatment group. Lymphocyte, platelets, and haemoglobin levels were significantly higher in the control group compared to the pre-treatment group. Acute phase reactants, NLR, NMR, PLR, d-NLR, MPVLR and systemic inflammatory index were significantly higher in all MIS-C patients on admission compared to the control group. Conclusion: Specific routine laboratory test results may be useful in determining disease severity of MIS-C, possibly predict the prognosis and allow early initiation of the appropriate treatment.https://dergipark.org.tr/tr/download/article-file/2377438disease severity; haematological parameters;inflammatory markers;multisystem inflammatory syndrome in childrendisease severityhaematological parameters;inflammatory markers;multisystem inflammatory syndrome in children |
| spellingShingle | Gülsüm Alkan Melike Emiroğlu Şadiye Kübra Tüter Öz Ahmet Sert Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome Genel Tıp Dergisi disease severity ; haematological parameters; inflammatory markers; multisystem inflammatory syndrome in children disease severity haematological parameters; inflammatory markers; multisystem inflammatory syndrome in children |
| title | Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome |
| title_full | Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome |
| title_fullStr | Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome |
| title_full_unstemmed | Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome |
| title_short | Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome |
| title_sort | hematological parameters and inflammatory markers in children with multisystem inflammatory syndrome |
| topic | disease severity ; haematological parameters; inflammatory markers; multisystem inflammatory syndrome in children disease severity haematological parameters; inflammatory markers; multisystem inflammatory syndrome in children |
| url | https://dergipark.org.tr/tr/download/article-file/2377438 |
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