Therapeutic tactics in abnormal uterine bleeding without anatomical substrate
The purpose of the review: presentation of modern data on the pathogenesis of abnormal uterine bleeding (AMC) without anatomical substrate (ovulatory, endometrial, coagulopathic) and the effectiveness of their treatment with medication.Basic provisions. Information on the pathogenesis of AMC not ass...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2019-01-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/2833 |
| _version_ | 1797842036266631168 |
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| author | G. В. Dikke |
| author_facet | G. В. Dikke |
| author_sort | G. В. Dikke |
| collection | DOAJ |
| description | The purpose of the review: presentation of modern data on the pathogenesis of abnormal uterine bleeding (AMC) without anatomical substrate (ovulatory, endometrial, coagulopathic) and the effectiveness of their treatment with medication.Basic provisions. Information on the pathogenesis of AMC not associated with structural abnormalities of the uterus is presented. It was shown that non-hormonal drugs have similar efficacy. Among the hormonal agents, levonorgestrel-containing intrauterine system (IUD-LNG) and estrogen-progestogen preparations (combined oral contraceptives, COCs) favorably differ. COCs recover an acute episode of AMC in 66.8% of cases (according to some data – in 88%), which is higher in comparison with non-hormonal drugs; in chronic cases – reduce blood loss by 88% (after 6 months of therapy), and are not inferior in effectiveness to intrauterine devices with levonorgestrel (83% after 3 months of therapy).The conclusion. Thus, non-hormonal drugs have similar efficacy in arresting AMC without an anatomical substrate, but are inferior to COCs. In case of chronic AMC, the first-line drugs are IUD-LNG and COC containing E2B / NNG, which contribute to the normalization of the menstrual cycle and the volume of menstrual blood loss with proven efficacy. |
| first_indexed | 2024-04-09T16:41:22Z |
| format | Article |
| id | doaj.art-575939ecf333417094189226865e7f12 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:41:22Z |
| publishDate | 2019-01-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-575939ecf333417094189226865e7f122023-04-23T06:56:39ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902019-01-0102116817210.21518/2079-701X-2018-21-168-1722767Therapeutic tactics in abnormal uterine bleeding without anatomical substrateG. В. Dikke0Peoples’ Friendship University of RussiaThe purpose of the review: presentation of modern data on the pathogenesis of abnormal uterine bleeding (AMC) without anatomical substrate (ovulatory, endometrial, coagulopathic) and the effectiveness of their treatment with medication.Basic provisions. Information on the pathogenesis of AMC not associated with structural abnormalities of the uterus is presented. It was shown that non-hormonal drugs have similar efficacy. Among the hormonal agents, levonorgestrel-containing intrauterine system (IUD-LNG) and estrogen-progestogen preparations (combined oral contraceptives, COCs) favorably differ. COCs recover an acute episode of AMC in 66.8% of cases (according to some data – in 88%), which is higher in comparison with non-hormonal drugs; in chronic cases – reduce blood loss by 88% (after 6 months of therapy), and are not inferior in effectiveness to intrauterine devices with levonorgestrel (83% after 3 months of therapy).The conclusion. Thus, non-hormonal drugs have similar efficacy in arresting AMC without an anatomical substrate, but are inferior to COCs. In case of chronic AMC, the first-line drugs are IUD-LNG and COC containing E2B / NNG, which contribute to the normalization of the menstrual cycle and the volume of menstrual blood loss with proven efficacy.https://www.med-sovet.pro/jour/article/view/2833abnormal uterine bleedinglevonorgestrel-containing intrauterine systemestradiol valeratedienogestgestagensnonsteroidal anti-inflammatory agentstranexamic acid |
| spellingShingle | G. В. Dikke Therapeutic tactics in abnormal uterine bleeding without anatomical substrate Медицинский совет abnormal uterine bleeding levonorgestrel-containing intrauterine system estradiol valerate dienogest gestagens nonsteroidal anti-inflammatory agents tranexamic acid |
| title | Therapeutic tactics in abnormal uterine bleeding without anatomical substrate |
| title_full | Therapeutic tactics in abnormal uterine bleeding without anatomical substrate |
| title_fullStr | Therapeutic tactics in abnormal uterine bleeding without anatomical substrate |
| title_full_unstemmed | Therapeutic tactics in abnormal uterine bleeding without anatomical substrate |
| title_short | Therapeutic tactics in abnormal uterine bleeding without anatomical substrate |
| title_sort | therapeutic tactics in abnormal uterine bleeding without anatomical substrate |
| topic | abnormal uterine bleeding levonorgestrel-containing intrauterine system estradiol valerate dienogest gestagens nonsteroidal anti-inflammatory agents tranexamic acid |
| url | https://www.med-sovet.pro/jour/article/view/2833 |
| work_keys_str_mv | AT gvdikke therapeutictacticsinabnormaluterinebleedingwithoutanatomicalsubstrate |