Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer

Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer

Cervical cancer development following a persistent infection with high-risk human papillomavirus (hrHPV) is driven by additional host-cell changes, such as altered DNA methylation. In previous studies, we have identified 12 methylated host genes associated with cervical cancer and pre-cancer (CIN2/3...

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Bibliographic Details
Main Authors: Wina Verlaat, Robert W. Van Leeuwen, Putri W. Novianti, Ed Schuuring, Chris J. L. M. Meijer, Ate G. J. Van Der Zee, Peter J. F. Snijders, Daniëlle A. M. Heideman, Renske D. M. Steenbergen, G. Bea A. Wisman
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:Epigenetics
Subjects:
cervical carcinogenesis
dna methylation markers
cervical scrapings
in vitro model
hrhpv
quantitative methylation-specific pcr (qmsp)
epigenetics
Online Access:http://dx.doi.org/10.1080/15592294.2018.1507197

Internet

http://dx.doi.org/10.1080/15592294.2018.1507197

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