A NEW MARKER OF METABOLIC DISORDERS IN MEN WITH TYPE 2 DIABETES
Purpose: to evaluate the effect of the degree of severity of obesity on metabolic profile, the LAP index, leptin levels and C-reactive protein (CRP) in men with type 2 diabetes c.Materials and methods: 120 male patients aged 40-65 years with obesity and Type 2 diabetes (mean age 54.3 ± 5.3 years). T...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2016-03-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/314 |
| Summary: | Purpose: to evaluate the effect of the degree of severity of obesity on metabolic profile, the LAP index, leptin levels and C-reactive protein (CRP) in men with type 2 diabetes c.Materials and methods: 120 male patients aged 40-65 years with obesity and Type 2 diabetes (mean age 54.3 ± 5.3 years). To assess the influence of the degree of severity of obesity on metabolic parameters was undertaken a comparative analysis of the data, depending on the body mass index (BMI). The metabolic profile was evaluated in terms of lipid profile, fasting glucose, of HbA1c, insulin resistance index HOMA. The study of leptin and CRP concentrations produced using laboratory kits for ELISA eBioscience (Austria). We used a new indicator for the integrated assessment of metabolic and cardio-vascular risks — LAP index.Results: analysis revealed no significant differences in fasting glucose, HbA1c and total cholesterol (TC) between the groups. In all groups, the study revealed an increase HOMA index from the first to the fourth group, which indicates an increase in the severity of insulin resistance.Summary: the increase in body mass index is a factor that by enhancing insulin resistance and adipokines production, leading to aggravation of metabolic disorders and the rise of cardiovascular risk in men with obesity and type 2 diabetes. LAP index is a more accurate marker of metabolic disorders than conventional carbohydrate and lipid metabolism. |
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| ISSN: | 2219-8075 2618-7876 |