ZFP57 regulates DNA methylation of imprinted genes to facilitate embryonic development of somatic cell nuclear transfer embryos in Holstein cows

ZFP57 regulates DNA methylation of imprinted genes to facilitate embryonic development of somatic cell nuclear transfer embryos in Holstein cows

ABSTRACT: Aberrant epigenetic nuclear reprogramming, especially imprinting pattern disorders, is one of the major causes of failure of clone development from somatic cell nuclear transfer (SCNT). Previous studies showed that ZFP57 is a key protein required for imprint maintenance after fertilization...

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Bibliographic Details
Main Authors: Tong Yu, Ru Meng, Weijia Song, Hongzheng Sun, Quanli An, Chengtu Zhang, Yong Zhang, Jianmin Su
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Dairy Science
Subjects:
nuclear reprogramming barrier
ZFP57
imprinted genes
DNA methylation
embryonic development
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030222006683

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