Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.

Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.

Improved helminth control is required to alleviate the global burden of schistosomiasis and schistosome-associated pathologies. Current control efforts rely on the anti-helminthic drug praziquantel (PZQ), which enhances immune responses to crude schistosome antigens but does not prevent re-infection...

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Bibliographic Details
Main Authors: Claire D Bourke, Norman Nausch, Nadine Rujeni, Laura J Appleby, François Trottein, Nicholas Midzi, Takafira Mduluza, Francisca Mutapi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4014416?pdf=render

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