Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography
Abstract Background Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical complications and an incomplete understanding of the mechanism by which ele...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Bioelectronic Medicine |
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| Online Access: | https://doi.org/10.1186/s42234-021-00074-8 |
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| author | Andrew Perley Mehrdad Roustaei Marcelo Aguilar-Rivera David C. Kunkel Tzung K. Hsiai Todd P. Coleman Parinaz Abiri |
| author_facet | Andrew Perley Mehrdad Roustaei Marcelo Aguilar-Rivera David C. Kunkel Tzung K. Hsiai Todd P. Coleman Parinaz Abiri |
| author_sort | Andrew Perley |
| collection | DOAJ |
| description | Abstract Background Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical complications and an incomplete understanding of the mechanism by which electrical stimulation affects physiology. Methods A leadless inductively-powered pacemaker was implanted on the gastric serosa in an anesthetized pig. Wireless pacing was performed at transmitter-to-receiver distances up to 20 mm, frequency of 0.05 Hz, and pulse width of 400 ms. Electrogastrogram (EGG) recordings using cutaneous and serosal electrode arrays were analyzed to compute spectral and spatial statistical parameters associated with the slow wave. Results Our data demonstrated evident change in EGG signal patterns upon initiation of pacing. A buffer period was noted before a pattern of entrainment appeared with consistent and low variability in slow wave direction. A spectral power increase in the EGG frequency band during entrainment also suggested that pacing increased strength of the slow wave. Conclusion Our preliminary in vivo study using wireless pacing and concurrent EGG recording established the foundations for a minimally invasive approach to understand and optimize the effect of pacing on gastric motor activity as a means to treat conditions of gastric dysmotility. |
| first_indexed | 2024-12-17T10:10:17Z |
| format | Article |
| id | doaj.art-575befb3255d45e7a7473c7d5554d6ee |
| institution | Directory Open Access Journal |
| issn | 2332-8886 |
| language | English |
| last_indexed | 2024-12-17T10:10:17Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Bioelectronic Medicine |
| spelling | doaj.art-575befb3255d45e7a7473c7d5554d6ee2022-12-21T21:53:03ZengBMCBioelectronic Medicine2332-88862021-08-01711810.1186/s42234-021-00074-8Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous ElectrogastrographyAndrew Perley0Mehrdad Roustaei1Marcelo Aguilar-Rivera2David C. Kunkel3Tzung K. Hsiai4Todd P. Coleman5Parinaz Abiri6Department of Bioengineering, University of California, San DiegoDepartment of Bioengineering, University of California, Los AngelesDepartment of Bioengineering, University of California, San DiegoDivision of Gastroenterology, University of California, San DiegoDepartment of Bioengineering, University of California, Los AngelesDepartment of Bioengineering, University of California, San DiegoDepartment of Bioengineering, University of California, Los AngelesAbstract Background Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical complications and an incomplete understanding of the mechanism by which electrical stimulation affects physiology. Methods A leadless inductively-powered pacemaker was implanted on the gastric serosa in an anesthetized pig. Wireless pacing was performed at transmitter-to-receiver distances up to 20 mm, frequency of 0.05 Hz, and pulse width of 400 ms. Electrogastrogram (EGG) recordings using cutaneous and serosal electrode arrays were analyzed to compute spectral and spatial statistical parameters associated with the slow wave. Results Our data demonstrated evident change in EGG signal patterns upon initiation of pacing. A buffer period was noted before a pattern of entrainment appeared with consistent and low variability in slow wave direction. A spectral power increase in the EGG frequency band during entrainment also suggested that pacing increased strength of the slow wave. Conclusion Our preliminary in vivo study using wireless pacing and concurrent EGG recording established the foundations for a minimally invasive approach to understand and optimize the effect of pacing on gastric motor activity as a means to treat conditions of gastric dysmotility.https://doi.org/10.1186/s42234-021-00074-8Gastric pacingGastric pacemakerWireless electrical stimulationWireless pacingElectrogastrogramElectrogastrography |
| spellingShingle | Andrew Perley Mehrdad Roustaei Marcelo Aguilar-Rivera David C. Kunkel Tzung K. Hsiai Todd P. Coleman Parinaz Abiri Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography Bioelectronic Medicine Gastric pacing Gastric pacemaker Wireless electrical stimulation Wireless pacing Electrogastrogram Electrogastrography |
| title | Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography |
| title_full | Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography |
| title_fullStr | Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography |
| title_full_unstemmed | Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography |
| title_short | Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography |
| title_sort | miniaturized wireless gastric pacing via inductive power transfer with non invasive monitoring using cutaneous electrogastrography |
| topic | Gastric pacing Gastric pacemaker Wireless electrical stimulation Wireless pacing Electrogastrogram Electrogastrography |
| url | https://doi.org/10.1186/s42234-021-00074-8 |
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