Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless Mice
Skin photoaging, which causes wrinkles, increased epidermal thickness, and rough skin texture, is induced by ultraviolet B (UVB) exposure. These symptoms by skin photoaging have been reported to be involved in the reduction of collagen by the expression of matrix metalloproteinases (MMPs) and activa...
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MDPI AG
2022-11-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/12/2343 |
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| author | Ji Yeon Lee Jeong-Yong Park YongGyeong Kim Chang-Ho Kang |
| author_facet | Ji Yeon Lee Jeong-Yong Park YongGyeong Kim Chang-Ho Kang |
| author_sort | Ji Yeon Lee |
| collection | DOAJ |
| description | Skin photoaging, which causes wrinkles, increased epidermal thickness, and rough skin texture, is induced by ultraviolet B (UVB) exposure. These symptoms by skin photoaging have been reported to be involved in the reduction of collagen by the expression of matrix metalloproteinases (MMPs) and activator protein-1 (AP-1). This study investigated the protective effects of <i>Bifidobacterium animalis subsp. lactis</i> MG741 (<i>Bi. lactis</i> MG741) in Hs-68 fibroblasts and hairless mice (HR-1) following UVB exposure. We demonstrated that the <i>Bi. lactis</i> MG741 reduces wrinkles and skin thickness by downregulating MMP-1 and MMP-3, phosphorylation of extracellular signal-regulated kinase (ERK), and c-FOS in fibroblasts and HR-1. Additionally, in UVB-irradiated dorsal skin of HR-1, <i>Bi. lactis</i> MG741 inhibits the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), an inflammation-related factor. Thus, <i>Bi. lactis</i> MG741 has the potential to prevent wrinkles and skin inflammation by modulating skin photoaging markers. |
| first_indexed | 2024-03-09T16:04:09Z |
| format | Article |
| id | doaj.art-575f0fc39f6b4ef6a9ffbc9f61dd68c4 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T16:04:09Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-575f0fc39f6b4ef6a9ffbc9f61dd68c42023-11-24T16:47:31ZengMDPI AGMicroorganisms2076-26072022-11-011012234310.3390/microorganisms10122343Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless MiceJi Yeon Lee0Jeong-Yong Park1YongGyeong Kim2Chang-Ho Kang3MEDIOGEN, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of KoreaMEDIOGEN, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of KoreaMEDIOGEN, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of KoreaMEDIOGEN, Co., Ltd., Biovalley 1-ro, Jecheon-si 27159, Republic of KoreaSkin photoaging, which causes wrinkles, increased epidermal thickness, and rough skin texture, is induced by ultraviolet B (UVB) exposure. These symptoms by skin photoaging have been reported to be involved in the reduction of collagen by the expression of matrix metalloproteinases (MMPs) and activator protein-1 (AP-1). This study investigated the protective effects of <i>Bifidobacterium animalis subsp. lactis</i> MG741 (<i>Bi. lactis</i> MG741) in Hs-68 fibroblasts and hairless mice (HR-1) following UVB exposure. We demonstrated that the <i>Bi. lactis</i> MG741 reduces wrinkles and skin thickness by downregulating MMP-1 and MMP-3, phosphorylation of extracellular signal-regulated kinase (ERK), and c-FOS in fibroblasts and HR-1. Additionally, in UVB-irradiated dorsal skin of HR-1, <i>Bi. lactis</i> MG741 inhibits the expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), an inflammation-related factor. Thus, <i>Bi. lactis</i> MG741 has the potential to prevent wrinkles and skin inflammation by modulating skin photoaging markers.https://www.mdpi.com/2076-2607/10/12/2343<i>Bifidobacterium animalis</i> ssp. <i>lactis</i> MG741matrix metalloproteinasesanti-photoagingultraviolet B |
| spellingShingle | Ji Yeon Lee Jeong-Yong Park YongGyeong Kim Chang-Ho Kang Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless Mice Microorganisms <i>Bifidobacterium animalis</i> ssp. <i>lactis</i> MG741 matrix metalloproteinases anti-photoaging ultraviolet B |
| title | Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless Mice |
| title_full | Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless Mice |
| title_fullStr | Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless Mice |
| title_full_unstemmed | Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless Mice |
| title_short | Protective Effect of <i>Bifidobacterium animalis</i> subs. <i>lactis</i> MG741 as Probiotics against UVB-Exposed Fibroblasts and Hairless Mice |
| title_sort | protective effect of i bifidobacterium animalis i subs i lactis i mg741 as probiotics against uvb exposed fibroblasts and hairless mice |
| topic | <i>Bifidobacterium animalis</i> ssp. <i>lactis</i> MG741 matrix metalloproteinases anti-photoaging ultraviolet B |
| url | https://www.mdpi.com/2076-2607/10/12/2343 |
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