Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

Chronic myeloid leukemia (CML) is a blood cancer characterized by dysregulated production of maturing myeloid cells driven by the product of the Philadelphia chromosome, the BCR-ABL1 tyrosine kinase. Tyrosine kinase inhibitors (TKIs) have proved effective in treating CML, but there is still a cohort...

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Bibliographic Details
Main Authors: Jonathan Rodriguez, Abdon Iniguez, Nilamani Jena, Prasanthi Tata, Zhong-Ying Liu, Arthur D Lander, John Lowengrub, Richard A Van Etten
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
cancer
nonlinear dynamics
hematopoiesis
treatment dynamics
mathematical model
chronic myeloid leukemia
Online Access:https://elifesciences.org/articles/84149

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