Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin Hydration

Mushrooms are edible fungi containing valuable nutrients. They provide attractive bio-active properties, which have confirmed anti-oxidants, anti-aging, and anti-inflammatory properties. Mushrooms possess abundant natural polymers affecting skin hydration and acting as moisturizers supporting skin b...

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Main Authors: Nichcha Nitthikan, Pimporn Leelapornpisid, Ornchuma Naksuriya, Nutjeera Intasai, Kanokwan Kiattisin
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cosmetics
Subjects:
Online Access:https://www.mdpi.com/2079-9284/10/5/145
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author Nichcha Nitthikan
Pimporn Leelapornpisid
Ornchuma Naksuriya
Nutjeera Intasai
Kanokwan Kiattisin
author_facet Nichcha Nitthikan
Pimporn Leelapornpisid
Ornchuma Naksuriya
Nutjeera Intasai
Kanokwan Kiattisin
author_sort Nichcha Nitthikan
collection DOAJ
description Mushrooms are edible fungi containing valuable nutrients. They provide attractive bio-active properties, which have confirmed anti-oxidants, anti-aging, and anti-inflammatory properties. Mushrooms possess abundant natural polymers affecting skin hydration and acting as moisturizers supporting skin barrier function. In this study, cloud ear mushroom (<i>Auricularia polytricha</i>) water extract (CW) was produced as a natural polymer to evaluate a new film-forming spray (FFS) containing CW to increase skin hydration and protect transepidermal water loss. CW contained polysaccharides as 748.2 ± 0.02 mg glucose/g extract. CW significantly inhibited the secretion of IL-6 and TNF-α and enhanced skin hydration by increasing aquaporin-3 (AQP3) and filaggrin (FLG) in HaCaT cells. The FFS was formulated using CW, sodium polystyrene sulfonate, and glycerin. The selected formulation contained brown <i>Agaricus bisporus</i> (BE-FFS) evaluated physical appearance, spray angle, spray pattern, and in vitro skin permeation. The BE-FFS has a transparent thin film with suitable occlusive properties, drying time, and physical appearance. Afterward, in vitro skin permeation and human hydration property studies presented the long-lasting effects and provided safety and hydration potential after 4 weeks of use. Overall, all results indicate that the BE-FFS is a natural film-forming spray for skin hydration improvement.
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spelling doaj.art-576257bd7aaa44c1a4c4dea7d78495072023-11-19T16:08:39ZengMDPI AGCosmetics2079-92842023-10-0110514510.3390/cosmetics10050145Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin HydrationNichcha Nitthikan0Pimporn Leelapornpisid1Ornchuma Naksuriya2Nutjeera Intasai3Kanokwan Kiattisin4PhD Degree Program in Pharmacy, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandSun Herb Thai Chinese Manufacturing, College of Pharmacy, Rangsit University, Pathum Thani 12000, ThailandDivision of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandMushrooms are edible fungi containing valuable nutrients. They provide attractive bio-active properties, which have confirmed anti-oxidants, anti-aging, and anti-inflammatory properties. Mushrooms possess abundant natural polymers affecting skin hydration and acting as moisturizers supporting skin barrier function. In this study, cloud ear mushroom (<i>Auricularia polytricha</i>) water extract (CW) was produced as a natural polymer to evaluate a new film-forming spray (FFS) containing CW to increase skin hydration and protect transepidermal water loss. CW contained polysaccharides as 748.2 ± 0.02 mg glucose/g extract. CW significantly inhibited the secretion of IL-6 and TNF-α and enhanced skin hydration by increasing aquaporin-3 (AQP3) and filaggrin (FLG) in HaCaT cells. The FFS was formulated using CW, sodium polystyrene sulfonate, and glycerin. The selected formulation contained brown <i>Agaricus bisporus</i> (BE-FFS) evaluated physical appearance, spray angle, spray pattern, and in vitro skin permeation. The BE-FFS has a transparent thin film with suitable occlusive properties, drying time, and physical appearance. Afterward, in vitro skin permeation and human hydration property studies presented the long-lasting effects and provided safety and hydration potential after 4 weeks of use. Overall, all results indicate that the BE-FFS is a natural film-forming spray for skin hydration improvement.https://www.mdpi.com/2079-9284/10/5/145cloud ear mushroom (<i>Auricularia polytricha</i>)film forming sprayaquaporin-3filaggrinskin hydration
spellingShingle Nichcha Nitthikan
Pimporn Leelapornpisid
Ornchuma Naksuriya
Nutjeera Intasai
Kanokwan Kiattisin
Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin Hydration
Cosmetics
cloud ear mushroom (<i>Auricularia polytricha</i>)
film forming spray
aquaporin-3
filaggrin
skin hydration
title Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin Hydration
title_full Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin Hydration
title_fullStr Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin Hydration
title_full_unstemmed Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin Hydration
title_short Multifunctional Biological Properties and Topical Film Forming Spray Base on <i>Auricularia polytricha</i> as a Natural Polysaccharide Containing Brown <i>Agaricus bisporus</i> Extract for Skin Hydration
title_sort multifunctional biological properties and topical film forming spray base on i auricularia polytricha i as a natural polysaccharide containing brown i agaricus bisporus i extract for skin hydration
topic cloud ear mushroom (<i>Auricularia polytricha</i>)
film forming spray
aquaporin-3
filaggrin
skin hydration
url https://www.mdpi.com/2079-9284/10/5/145
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