Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review.
<h4>Introduction</h4>Health state utility values (HSUV) for Type 2 diabetes mellitus (T2DM) complications are useful in economic evaluations to determine cost effectiveness of an intervention. However, there is a lack of reference ranges for different severity and stages of individual co...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297589&type=printable |
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| author | Michelle Hwee Pheng Tan Siew Chin Ong Nurul Ain Mohd Tahir Adliah Mhd Ali Norlaila Mustafa |
| author_facet | Michelle Hwee Pheng Tan Siew Chin Ong Nurul Ain Mohd Tahir Adliah Mhd Ali Norlaila Mustafa |
| author_sort | Michelle Hwee Pheng Tan |
| collection | DOAJ |
| description | <h4>Introduction</h4>Health state utility values (HSUV) for Type 2 diabetes mellitus (T2DM) complications are useful in economic evaluations to determine cost effectiveness of an intervention. However, there is a lack of reference ranges for different severity and stages of individual complications. This study aimed to provide an overview of HSUV decrement ranges for common T2DM complications focusing on different severity and stages of complications.<h4>Method</h4>A systematic search was conducted in MEDLINE, SCOPUS, WEB OF SCIENCE. (Jan 2000 to April 2022). Included studies for HSUV estimates were from outpatient setting, regardless of treatment types, complication stages, regions and HRQoL instruments. Health Related Quality of Life (HRQoL) outcomes was to be presented as HSUV decrement values, adjusted according to social demographics and comorbidities. Adjusted HSUV decrements were extracted and compiled according to individual complications. After which, subsequently grouped into mild or severe category for comparison.<h4>Results</h4>Searches identified 35 studies. The size of the study population ranged from 160 to 14,826. The HSUV decrement range was widest for cerebrovascular disease (stroke): -0.0060 to -0.0780 for mild stroke and -0.035 to -0.266 for severe stroke; retinopathy: mild (-0.005 to -0.0862), moderate (-0.0030 to -0.1845) and severe retinopathy (-0.023 to -0.2434); amputation: (-0.1050 to -0.2880). Different nature of complication severity defined in studies could be categorized into: those with acute nature, chronic with lasting effects, those with symptoms at early stage or those with repetitive frequency or episodes.<h4>Discussion</h4>Overview of HSUV decrement ranges across different stages of each T2DM diabetes-related complications shows that chronic complications with lasting impact such as amputation, severe stroke with sequelae and severe retinopathy with blindness were generally associated with larger HSUV decrement range. Considerable heterogeneities exist across the studies. Promoting standardized complication definitions and identifying the most influential health state stages on HSUV decrements may assist researchers for future cost-effectiveness studies. |
| first_indexed | 2024-04-24T11:18:01Z |
| format | Article |
| id | doaj.art-57636db2214d4df98dd4bb2c784d225a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-24T11:18:01Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-57636db2214d4df98dd4bb2c784d225a2024-04-11T05:31:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01194e029758910.1371/journal.pone.0297589Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review.Michelle Hwee Pheng TanSiew Chin OngNurul Ain Mohd TahirAdliah Mhd AliNorlaila Mustafa<h4>Introduction</h4>Health state utility values (HSUV) for Type 2 diabetes mellitus (T2DM) complications are useful in economic evaluations to determine cost effectiveness of an intervention. However, there is a lack of reference ranges for different severity and stages of individual complications. This study aimed to provide an overview of HSUV decrement ranges for common T2DM complications focusing on different severity and stages of complications.<h4>Method</h4>A systematic search was conducted in MEDLINE, SCOPUS, WEB OF SCIENCE. (Jan 2000 to April 2022). Included studies for HSUV estimates were from outpatient setting, regardless of treatment types, complication stages, regions and HRQoL instruments. Health Related Quality of Life (HRQoL) outcomes was to be presented as HSUV decrement values, adjusted according to social demographics and comorbidities. Adjusted HSUV decrements were extracted and compiled according to individual complications. After which, subsequently grouped into mild or severe category for comparison.<h4>Results</h4>Searches identified 35 studies. The size of the study population ranged from 160 to 14,826. The HSUV decrement range was widest for cerebrovascular disease (stroke): -0.0060 to -0.0780 for mild stroke and -0.035 to -0.266 for severe stroke; retinopathy: mild (-0.005 to -0.0862), moderate (-0.0030 to -0.1845) and severe retinopathy (-0.023 to -0.2434); amputation: (-0.1050 to -0.2880). Different nature of complication severity defined in studies could be categorized into: those with acute nature, chronic with lasting effects, those with symptoms at early stage or those with repetitive frequency or episodes.<h4>Discussion</h4>Overview of HSUV decrement ranges across different stages of each T2DM diabetes-related complications shows that chronic complications with lasting impact such as amputation, severe stroke with sequelae and severe retinopathy with blindness were generally associated with larger HSUV decrement range. Considerable heterogeneities exist across the studies. Promoting standardized complication definitions and identifying the most influential health state stages on HSUV decrements may assist researchers for future cost-effectiveness studies.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297589&type=printable |
| spellingShingle | Michelle Hwee Pheng Tan Siew Chin Ong Nurul Ain Mohd Tahir Adliah Mhd Ali Norlaila Mustafa Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review. PLoS ONE |
| title | Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review. |
| title_full | Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review. |
| title_fullStr | Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review. |
| title_full_unstemmed | Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review. |
| title_short | Health state utility values ranges across varying stages and severity of type 2 diabetes-related complications: A systematic review. |
| title_sort | health state utility values ranges across varying stages and severity of type 2 diabetes related complications a systematic review |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297589&type=printable |
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