Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies
Coronavirus disease 2019 (COVID-19) sequelae (or long COVID) has become a clinically significant concern. Several studies have reported the relationship between heart rate variability (HRV) parameters and COVID-19. This review investigates the long-term association between COVID-19 and HRV parameter...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/11/8/1095 |
| _version_ | 1797605290124771328 |
|---|---|
| author | Hyo-Weon Suh Chan-Young Kwon Boram Lee |
| author_facet | Hyo-Weon Suh Chan-Young Kwon Boram Lee |
| author_sort | Hyo-Weon Suh |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) sequelae (or long COVID) has become a clinically significant concern. Several studies have reported the relationship between heart rate variability (HRV) parameters and COVID-19. This review investigates the long-term association between COVID-19 and HRV parameters. Four electronic databases were searched up to 29 July 2022. We included observational studies comparing HRV parameters (measurement durations: 1 min or more) in participants with and without a history of COVID-19. We used assessment tools developed by the National Heart, Lung, and Blood Institute group to evaluate the methodological quality of included studies. Eleven cross-sectional studies compared HRV parameters in individuals who recovered from acute COVID-19 infection to controls (n = 2197). Most studies reported standard deviation of normal-to-normal intervals (SDNN) and root mean square of the successive differences. The methodological quality of the included studies was not optimal. The included studies generally found decreased SDNN and parasympathetic activity in post-COVID-19 individuals. Compared to controls, decreases in SDNN were observed in individuals who recovered from COVID-19 or had long COVID. Most of the included studies emphasized parasympathetic inhibition in post-COVID-19 conditions. Due to the methodological limitations of measuring HRV parameters, the findings should be further validated by robust prospective longitudinal studies. |
| first_indexed | 2024-03-11T04:58:57Z |
| format | Article |
| id | doaj.art-5764754bd1504a76af152fe9da730b50 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T04:58:57Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-5764754bd1504a76af152fe9da730b502023-11-17T19:26:23ZengMDPI AGHealthcare2227-90322023-04-01118109510.3390/healthcare11081095Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational StudiesHyo-Weon Suh0Chan-Young Kwon1Boram Lee2Health Policy Research Team, Division of Healthcare Research, National Evidence-Based Healthcare Collaborating Agency, 400 Neungdong-ro, Gwangjin-gu, Seoul 04933, Republic of KoreaDepartment of Oriental Neuropsychiatry, College of Korean Medicine, Dong-Eui University, Busan 47227, Republic of KoreaKM Science Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of KoreaCoronavirus disease 2019 (COVID-19) sequelae (or long COVID) has become a clinically significant concern. Several studies have reported the relationship between heart rate variability (HRV) parameters and COVID-19. This review investigates the long-term association between COVID-19 and HRV parameters. Four electronic databases were searched up to 29 July 2022. We included observational studies comparing HRV parameters (measurement durations: 1 min or more) in participants with and without a history of COVID-19. We used assessment tools developed by the National Heart, Lung, and Blood Institute group to evaluate the methodological quality of included studies. Eleven cross-sectional studies compared HRV parameters in individuals who recovered from acute COVID-19 infection to controls (n = 2197). Most studies reported standard deviation of normal-to-normal intervals (SDNN) and root mean square of the successive differences. The methodological quality of the included studies was not optimal. The included studies generally found decreased SDNN and parasympathetic activity in post-COVID-19 individuals. Compared to controls, decreases in SDNN were observed in individuals who recovered from COVID-19 or had long COVID. Most of the included studies emphasized parasympathetic inhibition in post-COVID-19 conditions. Due to the methodological limitations of measuring HRV parameters, the findings should be further validated by robust prospective longitudinal studies.https://www.mdpi.com/2227-9032/11/8/1095COVID-19SARS-CoV-2post-acute COVID-19 syndromeHRVlong COVIDSDNN |
| spellingShingle | Hyo-Weon Suh Chan-Young Kwon Boram Lee Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies Healthcare COVID-19 SARS-CoV-2 post-acute COVID-19 syndrome HRV long COVID SDNN |
| title | Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies |
| title_full | Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies |
| title_fullStr | Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies |
| title_full_unstemmed | Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies |
| title_short | Long-Term Impact of COVID-19 on Heart Rate Variability: A Systematic Review of Observational Studies |
| title_sort | long term impact of covid 19 on heart rate variability a systematic review of observational studies |
| topic | COVID-19 SARS-CoV-2 post-acute COVID-19 syndrome HRV long COVID SDNN |
| url | https://www.mdpi.com/2227-9032/11/8/1095 |
| work_keys_str_mv | AT hyoweonsuh longtermimpactofcovid19onheartratevariabilityasystematicreviewofobservationalstudies AT chanyoungkwon longtermimpactofcovid19onheartratevariabilityasystematicreviewofobservationalstudies AT boramlee longtermimpactofcovid19onheartratevariabilityasystematicreviewofobservationalstudies |