Models Derived from <italic toggle="yes">In Vitro</italic> Analyses of Spleen, Liver, and Lung Leukocyte Functions Predict Vaccine Efficacy against the <named-content content-type="genus-species">Francisella tularensis</named-content> Live Vaccine Strain (LVS)

Models Derived from <italic toggle="yes">In Vitro</italic> Analyses of Spleen, Liver, and Lung Leukocyte Functions Predict Vaccine Efficacy against the <named-content content-type="genus-species">Francisella tularensis</named-content> Live Vaccine Strain (LVS)

ABSTRACT Currently, there are no licensed vaccines and no correlates of protection against Francisella tularensis, which causes tularemia. We recently demonstrated that measuring in vitro control of intramacrophage bacterial growth by murine F. tularensis-immune splenocytes, as well as transcription...

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Bibliographic Details
Main Authors: Roberto De Pascalis, Alicia Y. Chou, Patrik Ryden, Nikki J. Kennett, Anders Sjöstedt, Karen L. Elkins
Format: Article
Language:English
Published: American Society for Microbiology 2014-05-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00936-13

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