Neuraminidase1 Inhibitor Protects Against Doxorubicin-Induced Cardiotoxicity via Suppressing Drp1-Dependent Mitophagy

Neuraminidase1 Inhibitor Protects Against Doxorubicin-Induced Cardiotoxicity via Suppressing Drp1-Dependent Mitophagy

Anthracyclines, such as doxorubicin (DOX), are among the effective chemotherapeutic drugs for various malignancies. However, their clinical use is limited by irreversible cardiotoxicity. This study sought to determine the role of neuraminidase 1 (NEU1) in DOX-induced cardiomyopathy and the potential...

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Bibliographic Details
Main Authors:	Yating Qin, Chao Lv, Xinxin Zhang, Weibin Ruan, Xiangyu Xu, Chen Chen, Xinyun Ji, Li Lu, Xiaomei Guo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	doxorubicin cardiotoxicity neuraminidase1 oseltamivir dynamin-related protein 1 (Drp1) mitophagy
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.802502/full

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