Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice

Gut Commensal Fungi Protect Against Acetaminophen-Induced Hepatotoxicity by Reducing Cyp2a5 Expression in Mice

Background and AimsDrug-induced liver injury (DILI) is a common cause of acute liver failure and represents a significant global public health problem. When discussing the gut-liver axis, although a great deal of research has focused on the role of gut microbiota in regulating the progression of DIL...

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Bibliographic Details
Main Authors: Zhuoen He, Yunong Zeng, Shuyu Li, Lizhen Lin, Ruisi Zhou, Fangzhao Wang, Wenjiao Yang, Yuhao Wu, Junhao Yang, Ali Chen, Zhang Wang, Hong Yang, Xiaoshan Zhao, Wei Xiao, Lei Li, Shenhai Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Microbiology
Subjects:
acetaminophen
gut fungi
Cyp2a5
acute liver injury
inflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.944416/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.944416/full

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