Multiple Sclerosis and Microbiome
The composition of microbiota and the gut-brain axis is increasingly considered a factor in the development of various pathological conditions. The etiology of multiple sclerosis (MS), a chronic autoimmune disease affecting the CNS, is complex and interactions within the gut-brain axis may be releva...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/3/433 |
| _version_ | 1827629333899902976 |
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| author | Jana Lizrova Preiningerova Zuzana Jiraskova Zakostelska Adhish Srinivasan Veronika Ticha Ivana Kovarova Pavlina Kleinova Helena Tlaskalova-Hogenova Eva Kubala Havrdova |
| author_facet | Jana Lizrova Preiningerova Zuzana Jiraskova Zakostelska Adhish Srinivasan Veronika Ticha Ivana Kovarova Pavlina Kleinova Helena Tlaskalova-Hogenova Eva Kubala Havrdova |
| author_sort | Jana Lizrova Preiningerova |
| collection | DOAJ |
| description | The composition of microbiota and the gut-brain axis is increasingly considered a factor in the development of various pathological conditions. The etiology of multiple sclerosis (MS), a chronic autoimmune disease affecting the CNS, is complex and interactions within the gut-brain axis may be relevant in the development and the course of MS. In this article, we focus on the relationship between gut microbiota and the pathophysiology of MS. We review the contribution of germ-free mouse studies to our understanding of MS pathology and its implications for treatment strategies to modulate the microbiome in MS. This summary highlights the need for a better understanding of the role of the microbiota in patients’ responses to disease-modifying drugs in MS and disease activity overall. |
| first_indexed | 2024-03-09T13:49:01Z |
| format | Article |
| id | doaj.art-57674fe666c54524b2ec712b2ae023e6 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T13:49:01Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-57674fe666c54524b2ec712b2ae023e62023-11-30T20:52:56ZengMDPI AGBiomolecules2218-273X2022-03-0112343310.3390/biom12030433Multiple Sclerosis and MicrobiomeJana Lizrova Preiningerova0Zuzana Jiraskova Zakostelska1Adhish Srinivasan2Veronika Ticha3Ivana Kovarova4Pavlina Kleinova5Helena Tlaskalova-Hogenova6Eva Kubala Havrdova7Department of Neurology and Centre of Clinical Neuroscience, First Medical Faculty, Charles University and General Medical Hospital in Prague, 12800 Prague, Czech RepublicLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, 14220 Prague, Czech RepublicDepartment of Neurology and Centre of Clinical Neuroscience, First Medical Faculty, Charles University and General Medical Hospital in Prague, 12800 Prague, Czech RepublicDepartment of Neurology and Centre of Clinical Neuroscience, First Medical Faculty, Charles University and General Medical Hospital in Prague, 12800 Prague, Czech RepublicDepartment of Neurology and Centre of Clinical Neuroscience, First Medical Faculty, Charles University and General Medical Hospital in Prague, 12800 Prague, Czech RepublicDepartment of Neurology and Centre of Clinical Neuroscience, First Medical Faculty, Charles University and General Medical Hospital in Prague, 12800 Prague, Czech RepublicLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, 14220 Prague, Czech RepublicDepartment of Neurology and Centre of Clinical Neuroscience, First Medical Faculty, Charles University and General Medical Hospital in Prague, 12800 Prague, Czech RepublicThe composition of microbiota and the gut-brain axis is increasingly considered a factor in the development of various pathological conditions. The etiology of multiple sclerosis (MS), a chronic autoimmune disease affecting the CNS, is complex and interactions within the gut-brain axis may be relevant in the development and the course of MS. In this article, we focus on the relationship between gut microbiota and the pathophysiology of MS. We review the contribution of germ-free mouse studies to our understanding of MS pathology and its implications for treatment strategies to modulate the microbiome in MS. This summary highlights the need for a better understanding of the role of the microbiota in patients’ responses to disease-modifying drugs in MS and disease activity overall.https://www.mdpi.com/2218-273X/12/3/433multiple sclerosismicrobiomegut-brain axisdisease-modifying drugs |
| spellingShingle | Jana Lizrova Preiningerova Zuzana Jiraskova Zakostelska Adhish Srinivasan Veronika Ticha Ivana Kovarova Pavlina Kleinova Helena Tlaskalova-Hogenova Eva Kubala Havrdova Multiple Sclerosis and Microbiome Biomolecules multiple sclerosis microbiome gut-brain axis disease-modifying drugs |
| title | Multiple Sclerosis and Microbiome |
| title_full | Multiple Sclerosis and Microbiome |
| title_fullStr | Multiple Sclerosis and Microbiome |
| title_full_unstemmed | Multiple Sclerosis and Microbiome |
| title_short | Multiple Sclerosis and Microbiome |
| title_sort | multiple sclerosis and microbiome |
| topic | multiple sclerosis microbiome gut-brain axis disease-modifying drugs |
| url | https://www.mdpi.com/2218-273X/12/3/433 |
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