Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China
ObjectiveThis study investigates the prognostic significance of inflammatory nutritional scores in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) undergoing neoadjuvant chemoimmunotherapy.MethodsA total of 190 LA-ESCC patients were recruited from three medical centers ac...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1279733/full |
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| author | Jinxin Xu Jinxin Xu Zhinuan Hong Zhinuan Hong Zhinuan Hong Zhinuan Hong Yingjie Cai Yingjie Cai Zhen Chen Zhen Chen Jingping Lin Xi Yuan Shuchen Chen Shuchen Chen Shuchen Chen Shuchen Chen Jinbiao Xie Mingqiang Kang Mingqiang Kang Mingqiang Kang Mingqiang Kang Sunkui Ke Sunkui Ke |
| author_facet | Jinxin Xu Jinxin Xu Zhinuan Hong Zhinuan Hong Zhinuan Hong Zhinuan Hong Yingjie Cai Yingjie Cai Zhen Chen Zhen Chen Jingping Lin Xi Yuan Shuchen Chen Shuchen Chen Shuchen Chen Shuchen Chen Jinbiao Xie Mingqiang Kang Mingqiang Kang Mingqiang Kang Mingqiang Kang Sunkui Ke Sunkui Ke |
| author_sort | Jinxin Xu |
| collection | DOAJ |
| description | ObjectiveThis study investigates the prognostic significance of inflammatory nutritional scores in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) undergoing neoadjuvant chemoimmunotherapy.MethodsA total of 190 LA-ESCC patients were recruited from three medical centers across China. Pre-treatment laboratory tests were utilized to calculate inflammatory nutritional scores. LASSO regression and multivariate logistic regression analyses were conducted to pinpoint predictors of pathological response. Kaplan-Meier and Cox regression analyses were employed to assess disease-free survival (DFS) prognostic factors.ResultsThe cohort comprised 154 males (81.05%) and 36 females (18.95%), with a median age of 61.4 years. Pathological complete response (pCR) was achieved in 17.38% of patients, while 44.78% attained major pathological response (MPR). LASSO and multivariate logistic regression analyses identified that hemoglobin, albumin, lymphocyte, and platelet (HALP) (P=0.02) as an independent predictors of MPR in LA-ESCC patients receiving neoadjuvant chemoimmunotherapy. Kaplan-Meier and log-rank tests indicated that patients with low HALP, MPR, ypT1-2, ypN0 and, ypTNM I stages had prolonged DFS (P < 0.05). Furthermore, univariate and multivariate Cox regression analyses underscored HALP (P = 0.019) and ypT (P = 0.029) as independent predictive factors for DFS in ESCC.ConclusionOur study suggests that LA-ESCC patients with lower pre-treatment HALP scores exhibit improved pathological response and reduced recurrence rate. As a comprehensive index of inflammatory nutritional status, pre-treatment HALP may be a reliable prognostic marker in ESCC patients undergoing neoadjuvant chemoimmunotherapy. |
| first_indexed | 2024-03-07T22:09:03Z |
| format | Article |
| id | doaj.art-5767608e05c64d86ba7390eb5915f610 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T22:09:03Z |
| publishDate | 2024-02-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-5767608e05c64d86ba7390eb5915f6102024-02-23T18:22:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.12797331279733Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in ChinaJinxin Xu0Jinxin Xu1Zhinuan Hong2Zhinuan Hong3Zhinuan Hong4Zhinuan Hong5Yingjie Cai6Yingjie Cai7Zhen Chen8Zhen Chen9Jingping Lin10Xi Yuan11Shuchen Chen12Shuchen Chen13Shuchen Chen14Shuchen Chen15Jinbiao Xie16Mingqiang Kang17Mingqiang Kang18Mingqiang Kang19Mingqiang Kang20Sunkui Ke21Sunkui Ke22Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, Xiamen, ChinaFujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery(Fujian Medical University), Fujian Province University, Fuzhou, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Zhongshan Hospital Xiamen University, Xiamen, ChinaFujian Medical University, Fuzhou, ChinaDepartment of Cardiothoracic Surgery, The Affiliated Hospital of Putian University, Putian, ChinaDepartment of Cardiothoracic Surgery, Putian Pulmonary Hospital, Putian, ChinaThe First Affiliated Hospital of Xiamen University, Xiamen, China0Fujian Rongcheng Judicial Compulsory Isolation Drug Rehabilitation Center, Fuzhou, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery(Fujian Medical University), Fujian Province University, Fuzhou, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, ChinaDepartment of Cardiothoracic Surgery, The Affiliated Hospital of Putian University, Putian, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaKey Laboratory of Cardio-Thoracic Surgery(Fujian Medical University), Fujian Province University, Fuzhou, ChinaKey Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, ChinaFujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, ChinaDepartment of Thoracic Surgery, Zhongshan Hospital Xiamen University, Xiamen, ChinaFujian Medical University, Fuzhou, ChinaObjectiveThis study investigates the prognostic significance of inflammatory nutritional scores in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC) undergoing neoadjuvant chemoimmunotherapy.MethodsA total of 190 LA-ESCC patients were recruited from three medical centers across China. Pre-treatment laboratory tests were utilized to calculate inflammatory nutritional scores. LASSO regression and multivariate logistic regression analyses were conducted to pinpoint predictors of pathological response. Kaplan-Meier and Cox regression analyses were employed to assess disease-free survival (DFS) prognostic factors.ResultsThe cohort comprised 154 males (81.05%) and 36 females (18.95%), with a median age of 61.4 years. Pathological complete response (pCR) was achieved in 17.38% of patients, while 44.78% attained major pathological response (MPR). LASSO and multivariate logistic regression analyses identified that hemoglobin, albumin, lymphocyte, and platelet (HALP) (P=0.02) as an independent predictors of MPR in LA-ESCC patients receiving neoadjuvant chemoimmunotherapy. Kaplan-Meier and log-rank tests indicated that patients with low HALP, MPR, ypT1-2, ypN0 and, ypTNM I stages had prolonged DFS (P < 0.05). Furthermore, univariate and multivariate Cox regression analyses underscored HALP (P = 0.019) and ypT (P = 0.029) as independent predictive factors for DFS in ESCC.ConclusionOur study suggests that LA-ESCC patients with lower pre-treatment HALP scores exhibit improved pathological response and reduced recurrence rate. As a comprehensive index of inflammatory nutritional status, pre-treatment HALP may be a reliable prognostic marker in ESCC patients undergoing neoadjuvant chemoimmunotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2024.1279733/fullesophageal squamous cell carcinomaneoadjuvant chemoimmunotherapyinflammatory nutritional scoreshemoglobin, albumin, lymphocyte, and plateletmajor pathological responsedisease-free survival |
| spellingShingle | Jinxin Xu Jinxin Xu Zhinuan Hong Zhinuan Hong Zhinuan Hong Zhinuan Hong Yingjie Cai Yingjie Cai Zhen Chen Zhen Chen Jingping Lin Xi Yuan Shuchen Chen Shuchen Chen Shuchen Chen Shuchen Chen Jinbiao Xie Mingqiang Kang Mingqiang Kang Mingqiang Kang Mingqiang Kang Sunkui Ke Sunkui Ke Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China Frontiers in Oncology esophageal squamous cell carcinoma neoadjuvant chemoimmunotherapy inflammatory nutritional scores hemoglobin, albumin, lymphocyte, and platelet major pathological response disease-free survival |
| title | Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China |
| title_full | Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China |
| title_fullStr | Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China |
| title_full_unstemmed | Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China |
| title_short | Prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy: a multicenter study in China |
| title_sort | prognostic value of inflammatory nutritional scores in locally advanced esophageal squamous cell carcinoma patients undergoing neoadjuvant chemoimmunotherapy a multicenter study in china |
| topic | esophageal squamous cell carcinoma neoadjuvant chemoimmunotherapy inflammatory nutritional scores hemoglobin, albumin, lymphocyte, and platelet major pathological response disease-free survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1279733/full |
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