CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis
The mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways, and this review will briefly describe only th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/5/2233 |
| _version_ | 1797395432433778688 |
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| author | Jilly Frances Evans Kseniya Obraztsova Susan M. Lin Vera P. Krymskaya |
| author_facet | Jilly Frances Evans Kseniya Obraztsova Susan M. Lin Vera P. Krymskaya |
| author_sort | Jilly Frances Evans |
| collection | DOAJ |
| description | The mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways, and this review will briefly describe only the key proteins and their intra- and extracellular crosstalk. These complex interactions will be discussed in relation to cancer development, drug resistance, and stem cell exhaustion. This review will also highlight the tumor-suppressive tuberous sclerosis complex (TSC) mutated, mTOR-hyperactive lung disease of women, lymphangioleiomyomatosis (LAM). We will summarize recent advances in the targeting of these pathways by monotherapy or combination therapy, as well as future potential treatments. |
| first_indexed | 2024-03-09T00:35:25Z |
| format | Article |
| id | doaj.art-5767bf4261a14591a0e352bda9b262e9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T00:35:25Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5767bf4261a14591a0e352bda9b262e92023-12-11T18:12:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01225223310.3390/ijms22052233CrossTORC and WNTegration in Disease: Focus on LymphangioleiomyomatosisJilly Frances Evans0Kseniya Obraztsova1Susan M. Lin2Vera P. Krymskaya3Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAThe mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways, and this review will briefly describe only the key proteins and their intra- and extracellular crosstalk. These complex interactions will be discussed in relation to cancer development, drug resistance, and stem cell exhaustion. This review will also highlight the tumor-suppressive tuberous sclerosis complex (TSC) mutated, mTOR-hyperactive lung disease of women, lymphangioleiomyomatosis (LAM). We will summarize recent advances in the targeting of these pathways by monotherapy or combination therapy, as well as future potential treatments.https://www.mdpi.com/1422-0067/22/5/2233mTORTSC1/2Wnt/β-cateninGSK3βcancerlymphangioleiomyomatosis |
| spellingShingle | Jilly Frances Evans Kseniya Obraztsova Susan M. Lin Vera P. Krymskaya CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis International Journal of Molecular Sciences mTOR TSC1/2 Wnt/β-catenin GSK3β cancer lymphangioleiomyomatosis |
| title | CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis |
| title_full | CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis |
| title_fullStr | CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis |
| title_full_unstemmed | CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis |
| title_short | CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis |
| title_sort | crosstorc and wntegration in disease focus on lymphangioleiomyomatosis |
| topic | mTOR TSC1/2 Wnt/β-catenin GSK3β cancer lymphangioleiomyomatosis |
| url | https://www.mdpi.com/1422-0067/22/5/2233 |
| work_keys_str_mv | AT jillyfrancesevans crosstorcandwntegrationindiseasefocusonlymphangioleiomyomatosis AT kseniyaobraztsova crosstorcandwntegrationindiseasefocusonlymphangioleiomyomatosis AT susanmlin crosstorcandwntegrationindiseasefocusonlymphangioleiomyomatosis AT verapkrymskaya crosstorcandwntegrationindiseasefocusonlymphangioleiomyomatosis |