Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives
Parkinson’s disease (PD) is one of the most common and chronic degenerative diseases in the central nervous system. The main pathology of PD formation is the progressive loss of dopaminergic neurons in substantia nigra and the formation of α-synuclein-rich Lewy bodies. The pathogenesis of PD is not...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.919233/full |
| _version_ | 1828315402567942144 |
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| author | Xin-xing Yang Rong Yang Feng Zhang Feng Zhang |
| author_facet | Xin-xing Yang Rong Yang Feng Zhang Feng Zhang |
| author_sort | Xin-xing Yang |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is one of the most common and chronic degenerative diseases in the central nervous system. The main pathology of PD formation is the progressive loss of dopaminergic neurons in substantia nigra and the formation of α-synuclein-rich Lewy bodies. The pathogenesis of PD is not caused by any single independent factor. The diversity of these independent factors of PD, such as iron accumulation, oxidative stress, neuroinflammation, mitochondrial dysfunction, age, environment, and heredity, makes the research progress of PD slow. Nrf2 has been well-known to be closely associated with the pathogenesis of PD and could regulate these induced factors development. Nrf2 activation could protect dopaminergic neurons and slow down the progression of PD. This review summarized the role of Nrf2 pathway on the pathogenesis of PD. Regulation of Nrf2 pathway might be one of the promising strategies to prevent and treat PD. |
| first_indexed | 2024-04-13T16:59:27Z |
| format | Article |
| id | doaj.art-5767e8149e4b4debbd4671e24ad83751 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T16:59:27Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5767e8149e4b4debbd4671e24ad837512022-12-22T02:38:43ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-06-011310.3389/fphar.2022.919233919233Role of Nrf2 in Parkinson’s Disease: Toward New PerspectivesXin-xing Yang0Rong Yang1Feng Zhang2Feng Zhang3Laboratory Animal Center and Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University, Zunyi, ChinaLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University, Zunyi, ChinaLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University, Zunyi, ChinaCollaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, ChinaParkinson’s disease (PD) is one of the most common and chronic degenerative diseases in the central nervous system. The main pathology of PD formation is the progressive loss of dopaminergic neurons in substantia nigra and the formation of α-synuclein-rich Lewy bodies. The pathogenesis of PD is not caused by any single independent factor. The diversity of these independent factors of PD, such as iron accumulation, oxidative stress, neuroinflammation, mitochondrial dysfunction, age, environment, and heredity, makes the research progress of PD slow. Nrf2 has been well-known to be closely associated with the pathogenesis of PD and could regulate these induced factors development. Nrf2 activation could protect dopaminergic neurons and slow down the progression of PD. This review summarized the role of Nrf2 pathway on the pathogenesis of PD. Regulation of Nrf2 pathway might be one of the promising strategies to prevent and treat PD.https://www.frontiersin.org/articles/10.3389/fphar.2022.919233/fullParkinson’s diseasepathogenesisNrf2neuroprotectionoxidative stress |
| spellingShingle | Xin-xing Yang Rong Yang Feng Zhang Feng Zhang Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives Frontiers in Pharmacology Parkinson’s disease pathogenesis Nrf2 neuroprotection oxidative stress |
| title | Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives |
| title_full | Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives |
| title_fullStr | Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives |
| title_full_unstemmed | Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives |
| title_short | Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives |
| title_sort | role of nrf2 in parkinson s disease toward new perspectives |
| topic | Parkinson’s disease pathogenesis Nrf2 neuroprotection oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.919233/full |
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