Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives

Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives

Parkinson’s disease (PD) is one of the most common and chronic degenerative diseases in the central nervous system. The main pathology of PD formation is the progressive loss of dopaminergic neurons in substantia nigra and the formation of α-synuclein-rich Lewy bodies. The pathogenesis of PD is not...

Full description

Bibliographic Details
Main Authors:	Xin-xing Yang, Rong Yang, Feng Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Pharmacology
Subjects:	Parkinson’s disease pathogenesis Nrf2 neuroprotection oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.919233/full

Similar Items

Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease
by: Yumin Wang, et al.
Published: (2021-11-01)

Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease
by: Francisca Villavicencio Tejo, et al.
Published: (2021-07-01)

The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice
by: Jun-Hui Yang, et al.
Published: (2018-10-01)

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
by: Alberto Delaidelli, et al.
Published: (2021-06-01)

Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson’s Disease Mouse Model
by: Jung-Eun Park, et al.
Published: (2023-11-01)

Z-ligustilide provides a neuroprotective effect by regulating the phenotypic polarization of microglia via activating Nrf2-TrxR axis in the Parkinson's disease mouse model
by: Shoujiao Peng, et al.
Published: (2024-10-01)

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s Disease
by: Manuj Ahuja, et al.
Published: (2022-09-01)

Natural Compounds That Activate the KEAP1/Nrf2 Signaling Pathway as Potential New Drugs in the Treatment of Idiopathic Parkinson’s Disease
by: Sandro Huenchuguala, et al.
Published: (2024-09-01)

Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications
by: Mengru Liu, et al.
Published: (2025-01-01)

Nrf2 Deficiency Exacerbates Parkinson’s Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells
by: Lu R, et al.
Published: (2024-09-01)

Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease
by: Pablo Duarte, et al.
Published: (2022-01-01)

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway
by: Xingfang Guo, et al.
Published: (2019-03-01)

A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases
by: Sarmistha Saha, et al.
Published: (2022-01-01)

Neuroprotective effects of dendrobium endophytes metabolites in SH-SY5Y cells via the Nrf2/Keap1 pathway
by: Yan tian Liang, et al.
Published: (2024-03-01)

Distinct Roles of Nrf1 and Nrf2 in Monitoring the Reductive Stress Response to Dithiothreitol (DTT)
by: Reziyamu Wufuer, et al.
Published: (2022-08-01)

A Pivotal Role of Nrf2 in Neurodegenerative Disorders: A New Way for Therapeutic Strategies
by: Sibel Suzen, et al.
Published: (2022-05-01)

Novel Prenylated Indole Alkaloids with Neuroprotection on SH-SY5Y Cells against Oxidative Stress Targeting Keap1–Nrf2
by: Xueyang Xiao, et al.
Published: (2022-03-01)

Neuroprotective effect of acetoxypachydiol against oxidative stress through activation of the Keap1-Nrf2/HO-1 pathway
by: Yu Qi, et al.
Published: (2024-04-01)

Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models
by: Qing Guo, et al.
Published: (2021-07-01)

Neuroprotective effects of Shende’an tablet in the Parkinson’s disease model
by: Xiaoyan Sheng, et al.
Published: (2021-02-01)

Effects of electroacupuncture on behavioral deficits, hippocampal neuronal death and oxidative stress in rats with parkinson"s disease
by: Dingding LIU, et al.
Published: (2024-09-01)

Thymoquinone Prevents Dopaminergic Neurodegeneration by Attenuating Oxidative Stress Via the Nrf2/ARE Pathway
by: Jianjian Dong, et al.
Published: (2021-01-01)

Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
by: Silvia Bono, et al.
Published: (2021-10-01)

Role of Nrf2 in Pancreatic Cancer
by: Marta Cykowiak, et al.
Published: (2021-12-01)

Formononetin Exerts Neuroprotection in Parkinson’s Disease via the Activation of the Nrf2 Signaling Pathway
by: Xiaotong Wang, et al.
Published: (2024-11-01)

Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-κB and p53 Pathways in Neurodegeneration
by: Maja Jazvinšćak Jembrek, et al.
Published: (2021-10-01)

Neuroprotective effects of chloroform and aqueous fractions of noni juice against t-Butyl hydroperoxide-induced oxidative damage in SH-SY5Y cells
by: Jianguo Chen, et al.
Published: (2018-12-01)

Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson’s Disease
by: Heng-Chung Kung, et al.
Published: (2021-07-01)

Neuroprotective Effects of the Cultivated Chondrus crispus in a C. elegans Model of Parkinson’s Disease
by: Jinghua Liu, et al.
Published: (2015-04-01)

The Antinociceptive Role of Nrf2 in Neuropathic Pain: From Mechanisms to Clinical Perspectives
by: Kestutis Petrikonis, et al.
Published: (2024-08-01)

Neuroprotection of round scad (Decapterus maruadsi) hydrolysate in glutamate-damaged PC12 cells: Possible involved signaling pathways and potential bioactive peptides
by: Qi Zhang, et al.
Published: (2020-01-01)

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson’s disease by promoting Nrf2/NQO-1 pathway
by: Huang Lijuan, et al.
Published: (2022-09-01)

Nrf2–ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin
by: Huihui Zhang, et al.
Published: (2019-02-01)

Huperzine A protects against traumatic brain injury through anti-oxidative effects via the Nrf2-ARE pathway
by: Zhengrong Mei, et al.
Published: (2021-10-01)

In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway
by: Chien-Wei Feng, et al.
Published: (2019-05-01)

Daidzein alleviates neuronal damage and oxidative stress via GSK3β/Nrf2 pathway in mice
by: Xuerui Wang, et al.
Published: (2022-05-01)

The Role of Nrf2 in Skeletal Muscle on Exercise Capacity
by: Yu Kitaoka
Published: (2021-10-01)

NADPH oxidase 2 activity in Parkinson's disease
by: Matthew T. Keeney, et al.
Published: (2022-08-01)

Curcumin and Neuroprotection: A Promising Herbal Strategy for Alzheimer’s and Parkinson’s Disease
by: Ibrahim G. Abdelrhman
Published: (2024-12-01)

Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells
by: Shannon R. Barwick, et al.
Published: (2021-06-01)