A Genetically Encoded Dark-to-Bright Biosensor for Visualisation of Granzyme-Mediated Cytotoxicity

A Genetically Encoded Dark-to-Bright Biosensor for Visualisation of Granzyme-Mediated Cytotoxicity

Granzyme B (GZMB) is a key enzyme released by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells to induce apoptosis in target cells. We designed a novel fluorogenic biosensor which is able to assess GZMB activity in a specific and sensitive manner. This cleavage-responsive sensor for T cel...

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Bibliographic Details
Main Authors: Christopher Bednar, Sabrina Kübel, Arne Cordsmeier, Brigitte Scholz, Hanna Menschikowski, Armin Ensser
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
granzyme B
fluorogenic biosensor
T cell cytotoxicity
CAR-T cells
Online Access:https://www.mdpi.com/1422-0067/24/17/13589

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