Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with low five-year survival rates of 8% by conventional treatment methods, e.g., chemotherapy, radiotherapy, and surgery. PDAC shows high resistance towards chemo- and radiotherapy and only 15–20% of all patients can have surgery. This dise...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/2782 |
| _version_ | 1797552344190156800 |
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| author | Ruben Verloy Angela Privat-Maldonado Evelien Smits Annemie Bogaerts |
| author_facet | Ruben Verloy Angela Privat-Maldonado Evelien Smits Annemie Bogaerts |
| author_sort | Ruben Verloy |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with low five-year survival rates of 8% by conventional treatment methods, e.g., chemotherapy, radiotherapy, and surgery. PDAC shows high resistance towards chemo- and radiotherapy and only 15–20% of all patients can have surgery. This disease is predicted to become the third global leading cause of cancer death due to its significant rise in incidence. Therefore, the development of an alternative or combinational method is necessary to improve current approaches. Cold atmospheric plasma (CAP) treatments could offer multiple advantages to this emerging situation. The plasma-derived reactive species can induce oxidative damage and a cascade of intracellular signaling pathways, which could lead to cell death. Previous reports have shown that CAP treatment also influences cells in the tumor microenvironment, such as the pancreatic stellate cells (PSCs). These PSCs, when activated, play a crucial role in the propagation, growth and survival of PDAC tumors. However, the effect of CAP on PSCs is not yet fully understood. This review focuses on the application of CAP for PDAC treatment and the importance of PSCs in the response to treatment. |
| first_indexed | 2024-03-10T15:59:42Z |
| format | Article |
| id | doaj.art-57695e03312a4f3b8f24b9da4734996d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:59:42Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-57695e03312a4f3b8f24b9da4734996d2023-11-20T15:23:29ZengMDPI AGCancers2072-66942020-09-011210278210.3390/cancers12102782Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate CellsRuben Verloy0Angela Privat-Maldonado1Evelien Smits2Annemie Bogaerts3Plasma Lab for Applications in Sustainability and Medicine-ANTwerp, University of Antwerp, 2610 Wilrijk, BelgiumPlasma Lab for Applications in Sustainability and Medicine-ANTwerp, University of Antwerp, 2610 Wilrijk, BelgiumCenter for Oncological Research, University of Antwerp, 2610 Wilrijk, BelgiumPlasma Lab for Applications in Sustainability and Medicine-ANTwerp, University of Antwerp, 2610 Wilrijk, BelgiumPancreatic ductal adenocarcinoma (PDAC) is a lethal disease with low five-year survival rates of 8% by conventional treatment methods, e.g., chemotherapy, radiotherapy, and surgery. PDAC shows high resistance towards chemo- and radiotherapy and only 15–20% of all patients can have surgery. This disease is predicted to become the third global leading cause of cancer death due to its significant rise in incidence. Therefore, the development of an alternative or combinational method is necessary to improve current approaches. Cold atmospheric plasma (CAP) treatments could offer multiple advantages to this emerging situation. The plasma-derived reactive species can induce oxidative damage and a cascade of intracellular signaling pathways, which could lead to cell death. Previous reports have shown that CAP treatment also influences cells in the tumor microenvironment, such as the pancreatic stellate cells (PSCs). These PSCs, when activated, play a crucial role in the propagation, growth and survival of PDAC tumors. However, the effect of CAP on PSCs is not yet fully understood. This review focuses on the application of CAP for PDAC treatment and the importance of PSCs in the response to treatment.https://www.mdpi.com/2072-6694/12/10/2782pancreatic cancerpancreatic ductal adenocarcinomapancreatic stellate cellscold atmospheric plasmatumor microenvironment |
| spellingShingle | Ruben Verloy Angela Privat-Maldonado Evelien Smits Annemie Bogaerts Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells Cancers pancreatic cancer pancreatic ductal adenocarcinoma pancreatic stellate cells cold atmospheric plasma tumor microenvironment |
| title | Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells |
| title_full | Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells |
| title_fullStr | Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells |
| title_full_unstemmed | Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells |
| title_short | Cold Atmospheric Plasma Treatment for Pancreatic Cancer–The Importance of Pancreatic Stellate Cells |
| title_sort | cold atmospheric plasma treatment for pancreatic cancer the importance of pancreatic stellate cells |
| topic | pancreatic cancer pancreatic ductal adenocarcinoma pancreatic stellate cells cold atmospheric plasma tumor microenvironment |
| url | https://www.mdpi.com/2072-6694/12/10/2782 |
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