Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

Optimizing the Intracellular Delivery of Therapeutic Anti-inflammatory TNF-α siRNA to Activated Macrophages Using Lipidoid-Polymer Hybrid Nanoparticles

RNA interference (RNAi) has an unprecedented potential as a therapeutic strategy for reversibly silencing the expression of any gene. Therapeutic delivery of the RNAi mediator, i.e., small interfering RNA (siRNA), can be used to address diseases characterized by gene overexpression, for example infl...

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Bibliographic Details
Main Authors: Abhijeet Lokras, Aneesh Thakur, Abishek Wadhwa, Kaushik Thanki, Henrik Franzyk, Camilla Foged
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
lipidoid-polymer hybrid nanoparticles
RNAi - RNA interference
siRNA - small interfering RNA
quality-by-design
TNF-α
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.601155/full

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